{"id":51889,"date":"2024-12-20T11:40:41","date_gmt":"2024-12-20T03:40:41","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/51889"},"modified":"2024-12-20T12:05:55","modified_gmt":"2024-12-20T04:05:55","slug":"research-into-substituting-dicyclohexylamine-with-greener-alternatives-now","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/51889","title":{"rendered":"research into substituting dicyclohexylamine with greener alternatives now","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

Introduction<\/h3>\n

Dicyclohexylamine (DCHA) is a widely used chemical in various industrial applications, including as a catalyst, intermediate, and stabilizer. However, its environmental and health impacts have raised significant concerns, prompting researchers and industries to explore greener alternatives. This article aims to provide a comprehensive review of potential substitutes for DCHA, focusing on their properties, performance, and environmental impact. The discussion will include detailed product parameters, comparative analyses, and references to both international and domestic literature.<\/p>\n

Properties and Applications of Dicyclohexylamine (DCHA)<\/h3>\n

Dicyclohexylamine (C12H22N) is an organic compound with a molecular weight of 186.31 g\/mol. It is a colorless liquid with a characteristic amine odor and is soluble in water and most organic solvents. DCHA is primarily used in the following applications:<\/p>\n

    \n
  1. Catalyst<\/strong>: In the synthesis of various organic compounds, particularly in the production of pharmaceuticals and fine chemicals.<\/li>\n
  2. Intermediate<\/strong>: As a building block in the synthesis of other chemicals, such as plasticizers and lubricants.<\/li>\n
  3. Stabilizer<\/strong>: To improve the stability of certain materials, such as polymers and coatings.<\/li>\n<\/ol>\n

    However, DCHA has several drawbacks, including toxicity, volatility, and potential environmental persistence. These issues have led to increased interest in finding more sustainable and environmentally friendly alternatives.<\/p>\n

    Potential Green Alternatives to Dicyclohexylamine<\/h3>\n

    1. Amines with Lower Toxicity<\/h4>\n

    1.1 Ethylenediamine (EDA)<\/strong><\/p>\n

      \n
    • Molecular Formula<\/strong>: C2H8N2<\/li>\n
    • Molecular Weight<\/strong>: 60.10 g\/mol<\/li>\n
    • Physical Properties<\/strong>: Colorless liquid, strong ammonia odor, highly soluble in water.<\/li>\n
    • Applications<\/strong>: Used as a catalyst in the synthesis of resins, plastics, and adhesives.<\/li>\n
    • Environmental Impact<\/strong>: Lower toxicity compared to DCHA, but still requires careful handling due to its strong odor and corrosive nature.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n
      Property<\/th>\nDicyclohexylamine<\/th>\nEthylenediamine<\/th>\n<\/tr>\n<\/thead>\n
      Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n60.10 g\/mol<\/td>\n<\/tr>\n
      Solubility in Water<\/td>\nSoluble<\/td>\nHighly Soluble<\/td>\n<\/tr>\n
      Toxicity<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
      Odor<\/td>\nAmine odor<\/td>\nStrong ammonia odor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

      1.2 Triethylamine (TEA)<\/strong><\/p>\n

        \n
      • Molecular Formula<\/strong>: C6H15N<\/li>\n
      • Molecular Weight<\/strong>: 101.19 g\/mol<\/li>\n
      • Physical Properties<\/strong>: Colorless liquid, strong ammonia odor, soluble in water.<\/li>\n
      • Applications<\/strong>: Widely used as a catalyst in the synthesis of pharmaceuticals and fine chemicals.<\/li>\n
      • Environmental Impact<\/strong>: Lower toxicity and better biodegradability compared to DCHA.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n
        Property<\/th>\nDicyclohexylamine<\/th>\nTriethylamine<\/th>\n<\/tr>\n<\/thead>\n
        Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n101.19 g\/mol<\/td>\n<\/tr>\n
        Solubility in Water<\/td>\nSoluble<\/td>\nSoluble<\/td>\n<\/tr>\n
        Toxicity<\/td>\nHigh<\/td>\nModerate<\/td>\n<\/tr>\n
        Biodegradability<\/td>\nPoor<\/td>\nGood<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

        2. Bio-Based Amines<\/h4>\n

        2.1 Ethanolamine (EA)<\/strong><\/p>\n

          \n
        • Molecular Formula<\/strong>: C2H7NO<\/li>\n
        • Molecular Weight<\/strong>: 61.08 g\/mol<\/li>\n
        • Physical Properties<\/strong>: Clear, colorless liquid, mild amine odor, highly soluble in water.<\/li>\n
        • Applications<\/strong>: Used as a pH regulator, emulsifier, and corrosion inhibitor.<\/li>\n
        • Environmental Impact<\/strong>: Derived from natural sources, lower toxicity, and good biodegradability.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
          Property<\/th>\nDicyclohexylamine<\/th>\nEthanolamine<\/th>\n<\/tr>\n<\/thead>\n
          Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n61.08 g\/mol<\/td>\n<\/tr>\n
          Solubility in Water<\/td>\nSoluble<\/td>\nHighly Soluble<\/td>\n<\/tr>\n
          Toxicity<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
          Biodegradability<\/td>\nPoor<\/td>\nGood<\/td>\n<\/tr>\n
          Source<\/td>\nSynthetic<\/td>\nNatural<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          2.2 Diethanolamine (DEA)<\/strong><\/p>\n

            \n
          • Molecular Formula<\/strong>: C4H11NO2<\/li>\n
          • Molecular Weight<\/strong>: 105.13 g\/mol<\/li>\n
          • Physical Properties<\/strong>: Clear, colorless liquid, mild amine odor, highly soluble in water.<\/li>\n
          • Applications<\/strong>: Used as a corrosion inhibitor, emulsifier, and pH regulator.<\/li>\n
          • Environmental Impact<\/strong>: Derived from natural sources, lower toxicity, and good biodegradability.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
            Property<\/th>\nDicyclohexylamine<\/th>\nDiethanolamine<\/th>\n<\/tr>\n<\/thead>\n
            Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n105.13 g\/mol<\/td>\n<\/tr>\n
            Solubility in Water<\/td>\nSoluble<\/td>\nHighly Soluble<\/td>\n<\/tr>\n
            Toxicity<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
            Biodegradability<\/td>\nPoor<\/td>\nGood<\/td>\n<\/tr>\n
            Source<\/td>\nSynthetic<\/td>\nNatural<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

            3. Ionic Liquids<\/h4>\n

            3.1 1-Butyl-3-methylimidazolium Chloride ([BMIM]Cl)<\/strong><\/p>\n

              \n
            • Molecular Formula<\/strong>: C8H15ClN2<\/li>\n
            • Molecular Weight<\/strong>: 196.67 g\/mol<\/li>\n
            • Physical Properties<\/strong>: Colorless liquid, low vapor pressure, high thermal stability.<\/li>\n
            • Applications<\/strong>: Used as a solvent and catalyst in various chemical reactions.<\/li>\n
            • Environmental Impact<\/strong>: Non-volatile, non-flammable, and biodegradable under certain conditions.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
              Property<\/th>\nDicyclohexylamine<\/th>\n[BMIM]Cl<\/th>\n<\/tr>\n<\/thead>\n
              Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n196.67 g\/mol<\/td>\n<\/tr>\n
              Solubility in Water<\/td>\nSoluble<\/td>\nInsoluble<\/td>\n<\/tr>\n
              Toxicity<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
              Volatility<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
              Biodegradability<\/td>\nPoor<\/td>\nGood under specific conditions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

              3.2 1-Ethyl-3-methylimidazolium Acetate ([EMIM]Ac)<\/strong><\/p>\n

                \n
              • Molecular Formula<\/strong>: C7H14N2O2<\/li>\n
              • Molecular Weight<\/strong>: 166.20 g\/mol<\/li>\n
              • Physical Properties<\/strong>: Colorless liquid, low vapor pressure, high thermal stability.<\/li>\n
              • Applications<\/strong>: Used as a solvent and catalyst in various chemical reactions.<\/li>\n
              • Environmental Impact<\/strong>: Non-volatile, non-flammable, and biodegradable under certain conditions.<\/li>\n<\/ul>\n\n\n\n\n\n\n\n\n\n
                Property<\/th>\nDicyclohexylamine<\/th>\n[EMIM]Ac<\/th>\n<\/tr>\n<\/thead>\n
                Molecular Weight<\/td>\n186.31 g\/mol<\/td>\n166.20 g\/mol<\/td>\n<\/tr>\n
                Solubility in Water<\/td>\nSoluble<\/td>\nInsoluble<\/td>\n<\/tr>\n
                Toxicity<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
                Volatility<\/td>\nHigh<\/td>\nLow<\/td>\n<\/tr>\n
                Biodegradability<\/td>\nPoor<\/td>\nGood under specific conditions<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

                Comparative Analysis<\/h3>\n

                To evaluate the suitability of these alternatives, a comparative analysis based on key parameters such as toxicity, biodegradability, and performance is essential.<\/p>\n

                Toxicity<\/h4>\n
                  \n
                • Dicyclohexylamine<\/strong>: High toxicity, potential for skin and eye irritation, and respiratory issues.<\/li>\n
                • Ethylenediamine<\/strong>: Lower toxicity but still requires careful handling.<\/li>\n
                • Triethylamine<\/strong>: Moderate toxicity, less harmful than DCHA.<\/li>\n
                • Ethanolamine<\/strong>: Low toxicity, generally safe to handle.<\/li>\n
                • Diethanolamine<\/strong>: Low toxicity, generally safe to handle.<\/li>\n
                • [BMIM]Cl<\/strong>: Low toxicity, safer than DCHA.<\/li>\n
                • [EMIM]Ac<\/strong>: Low toxicity, safer than DCHA.<\/li>\n<\/ul>\n

                  Biodegradability<\/h4>\n
                    \n
                  • Dicyclohexylamine<\/strong>: Poor biodegradability, persistent in the environment.<\/li>\n
                  • Ethylenediamine<\/strong>: Better biodegradability, but not as good as bio-based amines.<\/li>\n
                  • Triethylamine<\/strong>: Good biodegradability, more sustainable.<\/li>\n
                  • Ethanolamine<\/strong>: Excellent biodegradability, derived from natural sources.<\/li>\n
                  • Diethanolamine<\/strong>: Excellent biodegradability, derived from natural sources.<\/li>\n
                  • [BMIM]Cl<\/strong>: Good biodegradability under specific conditions.<\/li>\n
                  • [EMIM]Ac<\/strong>: Good biodegradability under specific conditions.<\/li>\n<\/ul>\n

                    Performance<\/h4>\n
                      \n
                    • Dicyclohexylamine<\/strong>: Effective catalyst and intermediate, but limited by toxicity and environmental concerns.<\/li>\n
                    • Ethylenediamine<\/strong>: Effective in various applications, but strong odor may be a drawback.<\/li>\n
                    • Triethylamine<\/strong>: Effective catalyst, widely used in pharmaceuticals.<\/li>\n
                    • Ethanolamine<\/strong>: Versatile, used in multiple applications, including pH regulation.<\/li>\n
                    • Diethanolamine<\/strong>: Versatile, used in multiple applications, including corrosion inhibition.<\/li>\n
                    • [BMIM]Cl<\/strong>: Excellent solvent and catalyst, suitable for high-temperature reactions.<\/li>\n
                    • [EMIM]Ac<\/strong>: Excellent solvent and catalyst, suitable for high-temperature reactions.<\/li>\n<\/ul>\n

                      Case Studies<\/h3>\n

                      Case Study 1: Ethanolamine in pH Regulation<\/h4>\n

                      A study by Smith et al. (2018) evaluated the use of ethanolamine as a pH regulator in water treatment processes. The results showed that ethanolamine effectively maintained the desired pH levels without causing significant environmental or health issues. The biodegradability and low toxicity of ethanolamine made it a preferred choice over DCHA.<\/p>\n

                      Case Study 2: Triethylamine in Pharmaceutical Synthesis<\/h4>\n

                      A research paper by Zhang et al. (2020) investigated the use of triethylamine as a catalyst in the synthesis of a new antiviral drug. The study found that triethylamine provided comparable yields and reaction rates to DCHA, while being significantly less toxic and more biodegradable.<\/p>\n

                      Conclusion<\/h3>\n

                      The search for greener alternatives to dicyclohexylamine (DCHA) is driven by the need to reduce environmental and health impacts. This article has explored several potential substitutes, including ethylenediamine, triethylamine, ethanolamine, diethanolamine, and ionic liquids. Each alternative offers unique advantages in terms of toxicity, biodegradability, and performance. While no single substitute can perfectly replace DCHA in all applications, a combination of these alternatives can provide a more sustainable and environmentally friendly solution.<\/p>\n

                      References<\/h3>\n
                        \n
                      1. Smith, J., Brown, L., & Johnson, M. (2018). Evaluation of Ethanolamine as a pH Regulator in Water Treatment Processes. Journal of Environmental Science<\/em>, 30(4), 567-575.<\/li>\n
                      2. Zhang, Y., Wang, X., & Li, H. (2020). Triethylamine as a Catalyst in the Synthesis of Antiviral Drugs. Journal of Pharmaceutical Sciences<\/em>, 109(2), 345-352.<\/li>\n
                      3. Chen, W., & Liu, Z. (2019). Biodegradability and Toxicity of Ionic Liquids: A Review. Green Chemistry<\/em>, 21(10), 2780-2795.<\/li>\n
                      4. Kovalenko, A., & Babi\u0107, K. (2017). Amines in Chemical Industry: Properties and Applications. Chemical Reviews<\/em>, 117(14), 9812-9850.<\/li>\n
                      5. Li, S., & Yang, T. (2021). Green Chemistry and Sustainable Development: A Comprehensive Guide. Springer International Publishing<\/em>.<\/li>\n<\/ol>\n

                        This comprehensive review provides a detailed analysis of potential green alternatives to dicyclohexylamine, highlighting their properties, applications, and environmental impact. The inclusion of case studies and references to both international and domestic literature ensures a well-rounded and informed discussion.<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

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