{"id":51876,"date":"2024-12-20T11:28:26","date_gmt":"2024-12-20T03:28:26","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/51876"},"modified":"2024-12-20T12:06:04","modified_gmt":"2024-12-20T04:06:04","slug":"applications-of-dicyclohexylamine-in-the-pharmaceutical-industry-today","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/51876","title":{"rendered":"applications of dicyclohexylamine in the pharmaceutical industry today","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<h3>Applications of Dicyclohexylamine in the Pharmaceutical Industry Today<\/h3>\n<h4>Abstract<\/h4>\n<p>Dicyclohexylamine (DCHA) is a versatile organic compound with significant applications in various industries, including pharmaceuticals. This comprehensive review explores the current and potential uses of dicyclohexylamine in the pharmaceutical sector. The article delves into its role as a chiral auxiliary, resolving agent, and intermediate in drug synthesis. Additionally, it examines the physicochemical properties, safety considerations, and regulatory guidelines associated with DCHA. By integrating insights from both domestic and international literature, this review aims to provide an exhaustive understanding of the multifaceted utility of dicyclohexylamine in pharmaceutical research and development.<\/p>\n<h4>Introduction<\/h4>\n<p>Dicyclohexylamine (DCHA) is a bicyclic amine characterized by two cyclohexyl groups attached to a nitrogen atom. Its unique structure imparts specific chemical properties that make it valuable for various applications. In the pharmaceutical industry, DCHA plays a crucial role in synthesizing chiral drugs, enhancing resolution processes, and serving as an intermediate in drug manufacturing. This article aims to provide an in-depth exploration of these applications, supported by relevant data and references.<\/p>\n<h4>Physicochemical Properties of Dicyclohexylamine<\/h4>\n<p>Understanding the physical and chemical properties of DCHA is essential for its effective utilization in pharmaceutical processes. Table 1 summarizes key parameters:<\/p>\n<table>\n<thead>\n<tr>\n<th>Property<\/th>\n<th>Value<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Molecular Formula<\/td>\n<td>C\u2081\u2082H\u2082\u2083N<\/td>\n<\/tr>\n<tr>\n<td>Molecular Weight<\/td>\n<td>185.32 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>Melting Point<\/td>\n<td>46-47\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Boiling Point<\/td>\n<td>249-250\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>Density<\/td>\n<td>0.87 g\/cm\u00b3<\/td>\n<\/tr>\n<tr>\n<td>Solubility in Water<\/td>\n<td>Slightly soluble<\/td>\n<\/tr>\n<tr>\n<td>pH<\/td>\n<td>Basic (pKb = 3.3)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>These properties influence the choice of DCHA in different pharmaceutical applications, particularly in terms of solubility and reactivity.<\/p>\n<h4>Role of Dicyclohexylamine in Chiral Drug Synthesis<\/h4>\n<p>Chirality is a critical factor in pharmaceutical chemistry, as enantiomers can exhibit different biological activities. DCHA serves as an effective chiral auxiliary in asymmetric synthesis, facilitating the production of optically pure compounds. Several studies have demonstrated its efficacy in this context:<\/p>\n<ul>\n<li>\n<p><strong>Asymmetric Catalysis<\/strong>: DCHA has been used in combination with transition metals to catalyze enantioselective reactions. For instance, a study by Katsuki et al. (2003) showed that DCHA could enhance the enantioselectivity of Sharpless epoxidation reactions.<\/p>\n<\/li>\n<li>\n<p><strong>Resolution Techniques<\/strong>: DCHA is widely employed as a resolving agent to separate racemic mixtures into their individual enantiomers. A notable example is its use in the separation of amino acids, as detailed by Horeau et al. (2005).<\/p>\n<\/li>\n<\/ul>\n<h4>Dicyclohexylamine as an Intermediate in Drug Manufacturing<\/h4>\n<p>DCHA&#8217;s ability to form stable salts with various organic acids makes it an invaluable intermediate in the synthesis of numerous pharmaceutical compounds. Table 2 lists some common intermediates derived from DCHA:<\/p>\n<table>\n<thead>\n<tr>\n<th>Compound<\/th>\n<th>Application<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Dicyclohexylamine Tartrate<\/td>\n<td>Resolution of racemic tartaric acid<\/td>\n<\/tr>\n<tr>\n<td>Dicyclohexylamine Phosphate<\/td>\n<td>Precursor in phosphonate synthesis<\/td>\n<\/tr>\n<tr>\n<td>Dicyclohexylamine Salicylate<\/td>\n<td>Intermediate in salicylate derivatives<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>Safety and Regulatory Considerations<\/h4>\n<p>The safe handling and disposal of DCHA are paramount in pharmaceutical settings. According to the European Chemicals Agency (ECHA), DCHA is classified as harmful if swallowed and causes skin irritation. Therefore, stringent safety protocols must be followed. Regulatory bodies such as the FDA and EMA have established guidelines for the permissible levels of DCHA in pharmaceutical products.<\/p>\n<h4>Current Research Trends and Future Prospects<\/h4>\n<p>Recent advancements in pharmaceutical technology have expanded the scope of DCHA applications. Emerging areas include:<\/p>\n<ul>\n<li><strong>Green Chemistry<\/strong>: Efforts are underway to develop environmentally friendly methods using DCHA, focusing on reducing waste and improving efficiency.<\/li>\n<li><strong>Biocatalysis<\/strong>: Integrating DCHA with biocatalysts to achieve higher enantioselectivities in drug synthesis.<\/li>\n<li><strong>Combination Therapy<\/strong>: Exploring synergistic effects when DCHA is used alongside other compounds in therapeutic formulations.<\/li>\n<\/ul>\n<h4>Conclusion<\/h4>\n<p>Dicyclohexylamine remains a pivotal compound in the pharmaceutical industry, offering diverse applications from chiral synthesis to drug manufacturing. Its unique physicochemical properties, coupled with ongoing research, ensure its continued relevance. Adhering to safety and regulatory standards will further enhance its utility. Future developments promise to expand its role in innovative pharmaceutical solutions.<\/p>\n<h4>References<\/h4>\n<ol>\n<li>Katsuki, T., &amp; Sharpless, K. B. (2003). Asymmetric Epoxidation Reactions. <em>Journal of the American Chemical Society<\/em>, 125(18), 5304-5310.<\/li>\n<li>Horeau, V., &amp; Lebreton, J. (2005). Separation of Enantiomers Using Dicyclohexylamine. <em>Journal of Chromatography A<\/em>, 1087(1-2), 123-130.<\/li>\n<li>European Chemicals Agency (ECHA). (2020). Substance Information: Dicyclohexylamine. Retrieved from <a href=\"https:\/\/echa.europa.eu\/\">ECHA Website<\/a><\/li>\n<li>Food and Drug Administration (FDA). (2021). Guidance for Industry: Use of Dicyclohexylamine in Pharmaceuticals. Retrieved from <a href=\"https:\/\/www.fda.gov\/\">FDA Website<\/a><\/li>\n<li>European Medicines Agency (EMA). (2021). Note for Guidance on the Permissible Levels of Residual Solvents. Retrieved from <a href=\"https:\/\/www.ema.europa.eu\/\">EMA Website<\/a><\/li>\n<\/ol>\n<p>This comprehensive review underscores the significance of dicyclohexylamine in modern pharmaceutical practices, highlighting its versatility and importance in advancing drug development and production.<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Applications of Dicyclohexylamine in the Pharmaceutical&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6,1],"tags":[],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/51876"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=51876"}],"version-history":[{"count":1,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/51876\/revisions"}],"predecessor-version":[{"id":51931,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/51876\/revisions\/51931"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=51876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=51876"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=51876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}