{"id":51861,"date":"2024-12-20T11:15:23","date_gmt":"2024-12-20T03:15:23","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/51861"},"modified":"2024-12-20T12:06:14","modified_gmt":"2024-12-20T04:06:14","slug":"migration-risk-assessment-of-cyclohexylamine-in-food-packaging-materials-and-regulatory-compliance","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/51861","title":{"rendered":"Migration Risk Assessment of Cyclohexylamine in Food Packaging Materials and Regulatory Compliance","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

Introduction<\/h3>\n

Cyclohexylamine (CHA) is an organic compound widely used in various industrial applications, including the production of resins, rubber, and plasticizers. In the context of food packaging materials, CHA can be present as a residual monomer or as a component of additives, such as plasticizers and curing agents. The migration of CHA from food packaging materials into foodstuffs poses potential health risks to consumers, necessitating a thorough risk assessment and regulatory compliance.<\/p>\n

This article aims to provide a comprehensive analysis of the migration risk of cyclohexylamine in food packaging materials, focusing on product parameters, regulatory standards, and risk assessment methodologies. The content will be structured to include an overview of CHA, its uses in food packaging, migration mechanisms, toxicological data, regulatory frameworks, and practical recommendations for compliance. Tables and figures will be used to enhance the clarity and accessibility of the information presented.<\/p>\n

Overview of Cyclohexylamine (CHA)<\/h3>\n

Chemical Properties and Uses<\/h4>\n

Cyclohexylamine (CHA) is a colorless liquid with a pungent odor. Its chemical formula is C6H11NH2, and it has a molecular weight of 101.16 g\/mol. CHA is primarily used as a raw material in the synthesis of various chemicals, including rubber accelerators, corrosion inhibitors, and plasticizers. In the food packaging industry, CHA is sometimes used as a curing agent for epoxy resins and as a plasticizer in polyvinyl chloride (PVC) films.<\/p>\n\n\n\n\n\n\n\n\n\n\n
Property<\/strong><\/th>\nValue<\/strong><\/th>\n<\/tr>\n<\/thead>\n
Molecular Formula<\/strong><\/td>\nC6H11NH2<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n101.16 g\/mol<\/td>\n<\/tr>\n
Boiling Point<\/strong><\/td>\n134.5\u00b0C<\/td>\n<\/tr>\n
Melting Point<\/strong><\/td>\n-17.9\u00b0C<\/td>\n<\/tr>\n
Density<\/strong><\/td>\n0.82 g\/cm\u00b3 at 20\u00b0C<\/td>\n<\/tr>\n
Solubility in Water<\/strong><\/td>\n10.8 g\/100 mL at 20\u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Applications in Food Packaging<\/h4>\n

In food packaging, CHA is primarily used in the following applications:<\/p>\n

    \n
  1. Epoxy Resins<\/strong>: CHA acts as a curing agent for epoxy resins, which are used in the production of coatings and adhesives for food packaging.<\/li>\n
  2. Plasticizers<\/strong>: CHA can be used as a plasticizer in PVC films, enhancing their flexibility and durability.<\/li>\n
  3. Corrosion Inhibitors<\/strong>: CHA is sometimes added to metal cans to prevent corrosion and ensure the integrity of the packaging.<\/li>\n<\/ol>\n

    Migration Mechanisms<\/h3>\n

    The migration of CHA from food packaging materials into foodstuffs can occur through several mechanisms:<\/p>\n

      \n
    1. Diffusion<\/strong>: CHA molecules can diffuse through the polymer matrix of the packaging material, especially under conditions of high temperature and prolonged contact time.<\/li>\n
    2. Partitioning<\/strong>: CHA can partition between the packaging material and the foodstuff, depending on the polarity and solubility of the food matrix.<\/li>\n
    3. Leaching<\/strong>: CHA can leach out of the packaging material when exposed to certain solvents or food simulants, such as water, ethanol, and acetic acid.<\/li>\n<\/ol>\n

      Toxicological Data<\/h3>\n

      Acute Toxicity<\/h4>\n