{"id":49494,"date":"2024-06-03T09:52:01","date_gmt":"2024-06-03T01:52:01","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/49494"},"modified":"2024-06-03T09:52:01","modified_gmt":"2024-06-03T01:52:01","slug":"barbiturates","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/49494","title":{"rendered":"Barbiturates","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-49493\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/06\/3a2d0d9dbc1e4693a581ef0b498631c1.gif\" width=\"193\" height=\"227\" alt=\"Barbiturate structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>018M<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C8H12N2O3<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>184.19<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         5,5-diethylbarbituric acid,<\/p>\n<p>                         5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione,<\/p>\n<p>                          5,5-Diethylbarbituric acid,<\/p>\n<p>                          Barbitone,<\/p>\n<p>                          Veronal<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>57-44-3<\/p>\n<p><b>MDL number:<\/b>MFCD00036212<\/p>\n<p><b>EINECS number:<\/b>200-331-2<\/p>\n<p><b>RTECS number:<\/b>CQ3500000<\/p>\n<p><b>BRN number:<\/b>163999<\/p>\n<p><b>PubChem number:<\/b>24891513<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Characteristics:<\/SPAN>  <SPAN>White Needle  crystalline or crystalline powder.  Odorless.  Slightly bitter.  Sublime in a vacuum.  <\/SPAN><SPAN> <SPAN><\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Density (<\/SPAN>  <SPAN>g\/mL,25\/4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Relative vapor density (<\/SPAN><SPAN>g\/mL,<\/SPAN><SPAN>air<\/SPAN><SPAN>=1<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Melting point (<\/SPAN>  <SPAN>\u00baC<\/SPAN><SPAN>): <\/SPAN><SPAN>188<\/SPAN><SPAN>\uff5e<\/SPAN><SPAN>192<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Boiling point (<\/SPAN>  <SPAN>\u00baC,<\/SPAN><SPAN>Normal pressure): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Boiling point (<\/SPAN>  <SPAN>\u00baC,5.2kPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>fold\ufffdRate: Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Flashpoint (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Specific optical rotation (<\/SPAN><SPAN>\u00ba<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Autoignition point or ignition temperature  (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Not  OK<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Vapor pressure (<\/SPAN><SPAN>kPa,25\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Saturation vapor pressure (<\/SPAN><SPAN>kPa,60\u00baC<\/SPAN><SPAN>): Undetermined  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>heat of combustion (<\/SPAN><SPAN>KJ\/mol<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Critical temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>15.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Critical Pressure (<\/SPAN><SPAN>KPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>16.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Oil and water (octanol<\/SPAN><SPAN>\/<\/SPAN><SPAN>Water) partition coefficient pair  Value: Undetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>17.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Not  OK<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <SPAN><SPAN>18.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Lower explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>19.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Solubility:<\/SPAN><SPAN>1g<\/SPAN><SPAN>Product dissolves in approx.<\/SPAN><SPAN>130ml<\/SPAN><SPAN>Cold water,<\/SPAN><SPAN>13ml<\/SPAN><SPAN>Boiling water,<\/SPAN><SPAN>14ml<\/SPAN><SPAN>Ethanol,<\/SPAN><SPAN>75ml<\/SPAN><SPAN>Chloroform and<\/SPAN><SPAN>25ml<\/SPAN><SPAN>Ether, soluble in acetone, ethyl acetate, petroleum  Ether, acetic acid, amyl alcohol, pyridine, aniline, nitrobenzene and alkaline solutions<\/SPAN><SPAN>.  <\/SPAN><SPAN><\/SPAN>  <\/P>\n     <\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>5. Molecular property data:<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Molar refractive index: <\/SPAN>  <SPAN>44.09<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Molar volume (<\/SPAN><SPAN>m<SUP>3<\/SUP>\/mol<\/SPAN><SPAN>):<\/SPAN><SPAN>161.5<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>isotonic specific volume (<\/SPAN><SPAN>90.2K<\/SPAN><SPAN>):<\/SPAN><SPAN>389.1<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Surface Tension (<\/SPAN><SPAN>dyne\/cm<\/SPAN><SPAN>):<\/SPAN><SPAN>33.6<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Polarizability<\/SPAN><SPAN>\uff08<\/SPAN><SPAN>10<SUP>-24<\/SUP>cm<SUP>3<\/SUP><\/SPAN><SPAN>):<\/SPAN><SPAN>17.47<\/SPAN><\/P>\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 2<\/p>\n<p>3. Number of hydrogen bond acceptors: 3<\/p>\n<p>4. Number of rotatable chemical bonds: 2<\/p>\n<p>5. Number of tautomers: 5<\/p>\n<p>6. Topological molecule polar surface area 75.3<\/p>\n<p>7. Number of heavy atoms: 13<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 247<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN> <\/SPAN><SPAN>This product should be kept sealed.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN>Diethyl malonate is obtained by ethylation, cyclization and acidification.<\/SPAN><B><SPAN>  <\/SPAN><\/B><\/P>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     <SPAN>Prepare buffer solution.  Protein electrophoresis.  Liver function tests.  Hydrogen peroxide stabilizer.  <\/SPAN><br \/>\n <SPAN><br \/>\n <P class=\"MsoNormal\"><SPAN>This product can be used as a hypnotic drug. Due to reasons such as safety, effectiveness and drug resistance caused by repeated use, the use of barbiturates as hypnotic drugs has tended to decrease.  Barbiturate tablets were released by the Department of Health<\/SPAN><SPAN>1982<\/SPAN><SPAN>year<\/SPAN><SPAN>9<\/SPAN><SPAN>One \u200b\u200bof the eliminated drugs announced in March.  Barbiturates can be used as hydrogen peroxide stabilizers; used in the preparation of buffer solutions, protein electrophoresis, liver function testing, etc.  <\/SPAN><SPAN><\/SPAN><\/P><\/SPAN>\n     <\/p>\n<p>     extended-reading:<a href=\"https:\/\/www.cyclohexylamine.net\/pc-cat-np93-tegoamin-as-1\/\">https:\/\/www.cyclohexylamine.net\/pc-cat-np93-tegoamin-as-1\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/kosmos-29-catalyst-cas301-10-0-degussa-ag\/\">https:\/\/www.bdmaee.net\/kosmos-29-catalyst-cas301-10-0-degussa-ag\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/pentamethyldipropylenetriamine-cas3855-32-1-nnnnn-pentamethyldipropylenetriamine\/\">https:\/\/www.bdmaee.net\/pentamethyldipropylenetriamine-cas3855-32-1-nnnnn-pentamethyldipropylenetriamine\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/170\">https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/170<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31.jpg<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/monobutyltin-oxide\/\">https:\/\/www.bdmaee.net\/monobutyltin-oxide\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44912\">https:\/\/www.newtopchem.com\/archives\/44912<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44310\">https:\/\/www.newtopchem.com\/archives\/44310<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/hydroxy-nnn-trimethyl-1-propylamine-formate-cas62314-25-4-catalyst-tmr-2\/\">https:\/\/www.bdmaee.net\/hydroxy-nnn-trimethyl-1-propylamine-formate-cas62314-25-4-catalyst-tmr-2\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.cyclohexylamine.net\/dabco-t-12-niax-d-22\/\">https:\/\/www.cyclohexylamine.net\/dabco-t-12-niax-d-22\/<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 018M Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":49493,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15488],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49494"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=49494"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49494\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/49493"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=49494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=49494"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=49494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}