{"id":48973,"date":"2024-05-20T17:30:12","date_gmt":"2024-05-20T09:30:12","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/48973"},"modified":"2024-05-20T17:30:12","modified_gmt":"2024-05-20T09:30:12","slug":"l-isoleucine","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/48973","title":{"rendered":"L-isoleucine","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-48972\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/05\/28aee70604fb44be8b3142649c979d77.gif\" width=\"249\" height=\"198\" alt=\"L-isoleucine structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01HE<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C6H13NO2<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>131.17<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         \u03b1-amino-\u03b2-methylvaleric acid,<\/p>\n<p>                         L-isofluorescent amino acid,<\/p>\n<p>                         isoleucine,<\/p>\n<p>                         L-2-Amino-3-methylpentanoic acid,<\/p>\n<p>                         (2S,3S)2-Amino-3-methylpentanoic acid,<\/p>\n<p>                         L-a-Amino-b-methylvaleric Acid,<\/p>\n<p>                         L-2-Amino-3-methylvaleric Acid,<\/p>\n<p>                         nutritional supplements,<\/p>\n<p>                         Intermediates<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>73-32-5<\/p>\n<p><b>MDL number:<\/b>MFCD00064222<\/p>\n<p><b>EINECS number:<\/b>200-798-2<\/p>\n<p><b>RTECS number:<\/b>NR4705000<\/p>\n<p><b>BRN number:<\/b>1721792<\/p>\n<p><b>PubChem number:<\/b>24902116<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     1. Properties: White crystal flakes or crystalline powder, which can form rhombus leaves or flake crystals when crystallized in ethanol.  Odorless, slightly bitter.  2. Density (g\/mL, 25\/4\u2103): 1.035<\/p>\n<p>3. Relative vapor density (g\/mL, air=1): Uncertain<\/p>\n<p>4. Melting point (\u00baC): 284  (dec.)(lit.)<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Uncertain<\/p>\n<p>6. Boiling point (\u00baC, 5.2 kPa): Uncertain<\/p>\n<p>7. Refractive index: 40.5 \u00b0 (C=4, 6mol\/L HCl)<\/p>\n<p>8. Flash point (\u00baC): 168-170<\/p>\n<p>9. Specific rotation  (\u00ba): 41 \u00ba (c=4, 6N HCl)<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Uncertain<\/p>\n<p>11. Vapor pressure (kPa, 25  \u00baC): Uncertain<\/p>\n<p>12. Saturated vapor pressure (kPa, 60 \u00baC): Uncertain<\/p>\n<p>13. Heat of combustion (KJ\/mol): Uncertain<\/p>\n<p>14. Critical temperature (\u00baC): Uncertain<\/p>\n<p>15. Critical pressure (KPa): Uncertain<\/p>\n<p>16. Log value of oil-water (octanol\/water) partition coefficient  : Uncertain<\/p>\n<p>17. Explosion upper limit (%, V\/V): Uncertain<\/p>\n<p>18. Explosion lower limit (%, V\/V): Uncertain<\/p>\n<p>19. Solubility: Solubility in water is 41.2 g\/L (25\u00b0C), insoluble in hot alcohol (0.13% at 80\u00b0C) and hot acetic acid, insoluble in ether<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     Acute toxicity: rat abdominal LD50: 6822 mg\/kg; mutagenicity: human lymphocyte sister chromatid exchange test system: 10 mg\/L;\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p> 1. Molar refraction\ufffd\ufffd: 34.86<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 126.6<\/p>\n<p>3. Isotonic specific volume (90.2K): 316.4<\/p>\n<p>4. Surface tension (dyne\/cm): 39.0<\/p>\n<p>5. Polarizability (10<sup>-24<\/sup>cm<sup>3<\/sup>): 13.82  <\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Hydrophobic parameter calculation reference value (XlogP): -1.7<\/p>\n<p>2. Number of hydrogen bond donors: 2<\/p>\n<p>3. Number of hydrogen bond acceptors: 3<\/p>\n<p>  p&gt;<\/p>\n<p>4. Number of rotatable chemical bonds: 3<\/p>\n<p>5. Topological molecular polar surface area (TPSA): 63.3<\/p>\n<p>6. Number of heavy atoms: 9<\/p>\n<p>7. Surface charge: 0<\/p>\n<p>8. Complexity: 103<\/p>\n<p>9. Number of isotope atoms: 0<\/p>\n<p>10. Determine the atomic stereocenter  Number: 2<\/p>\n<p>11. Number of uncertain atomic stereocenters: 0<\/p>\n<p>12. Number of determined chemical bond stereocenters: 0<\/p>\n<p>13. Uncertain chemical bonds  Number of stereocenters: 0<\/p>\n<p>14, Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p><p>1. Found in flue-cured tobacco leaves and burley tobacco leaves.  <\/p>\n<p>2. The L-body has a bitter taste.  <\/p>\n<\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>Sealed packaging in brown glass bottles.  Store in a cool, dry place away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>1. It is obtained from sugar, ammonia and D-threonine through fermentation of S. marcescens.  Or it can be obtained by using sugar, ammonia and \u03b1-aminobutyric acid as raw materials, fermenting it with Pediococcus xanthus or Citrobacter striatum and then refining it.  <\/p>\n<p>2. Bacteria culture and fermentation fermentation broth filter the upper liquid oxalic acid, and H2SO4 filters the filtrate for adsorption.  <\/p>\n<p>3. Elution, concentration of eluate, distillation under reduced pressure, decolorization, concentration under pressure, distillation, neutralization of ammonia solution, precipitation, purification and crystallization.  <\/p>\n<p>4. Dry the finished product of L-isoleucine at 105\u2103.  <\/p>\n<p>5. Tobacco: BU, 22; FC, 21; Synthesis: It can be hydrolyzed and refined from proteins such as corn protein.  It can also be synthesized chemically.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>Can be used as a nutritional supplement to fortify various foods.  It can also be used in medicine as an ingredient in amino acid preparations.  <\/p>\n<\/p>\n<p>     extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/1112\">https:\/\/www.newtopchem.com\/archives\/1112<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/dioctyl-dimaleate-di-n-octyl-tin\/\">https:\/\/www.bdmaee.net\/dioctyl-dimaleate-di-n-octyl-tin\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/34\">https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/34<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/cas-2273-43-0-2\/\">https:\/\/www.bdmaee.net\/cas-2273-43-0-2\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/776\">https:\/\/www.newtopchem.com\/archives\/776<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/fascat4100-catalyst\/\">https:\/\/www.bdmaee.net\/fascat4100-catalyst\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44558\">https:\/\/www.newtopchem.com\/archives\/44558<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Dibutyltin-monooctyl-maleate-CAS25168-21-2-BT-58C.pdf\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Dibutyltin-monooctyl-maleate-CAS25168-21-2-BT-58C.pdf<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31-13.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31-13.jpg<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/dichlorodi-n-octylstannane\/\">https:\/\/www.bdmaee.net\/dichlorodi-n-octylstannane\/<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01HE Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48972,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15356],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48973"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48973"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48973\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48972"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48973"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}