<\/p>\n
Structural formula<\/p>\n
2,4-Dichlorophenoxyacetic acid,<\/p>\n
(2,4-Dichlorophenoxy)acetic acid,<\/p>\n
Two to four drops of 2,4-D acid,<\/p>\n
(2,4-dichlorophenoxy)-Acetic acid,<\/p>\n
herbicide<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
CAS number:<\/b>94-75-7<\/p>\n
MDL number:<\/b>MFCD00004300<\/p>\n
EINECS number:<\/b>202-361-1<\/p>\n
RTECS number:<\/b>AG6825000<\/p>\n
BRN number:<\/b>1214242<\/p>\n
PubChem number:<\/b>24868891<\/p>\nPhysical property data<\/h2>\n
1. Properties: White to yellow, crystal powder, odorless, industrial product with slight phenol smell. <\/p>\n
2. Density (g\/mL, 20\u2103): 1.563<\/p>\n
3. Relative vapor density (g\/mL, air=1): 7.63<\/p>\n
4. Melting point (\u00baC): 138<\/p>\n
5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n
6. Boiling point (\u00baC, 0.05KPa): 160<\/p>\n
7. Refractive index: Undetermined<\/p>\n
8. Flash point (\u00baC): Undetermined<\/p>\n
9. Specific rotation (\u00ba): Undetermined<\/p>\n
10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n
11. Vapor pressure (mmHg, \u00baC): Undetermined<\/p>\n
12. Saturated vapor pressure (kPa, 160\u00baC ): 0.053<\/p>\n
13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n
14. Critical temperature (\u00baC): Undetermined<\/p>\n
15. Critical pressure (KPa): Undetermined<\/p>\n
16. Log value of oil-water (octanol\/water) partition coefficient: Undetermined<\/p>\n
17. Explosion upper limit (%, V\/V): Undetermined Determined<\/p>\n
18. Lower explosion limit (%, V\/V): Undetermined<\/p>\n
19. Solubility: Slightly soluble in water, slightly soluble in oil, soluble in ethanol, etc. <\/p>\n<\/p>\n
1. Acute toxicity: Rat oral LD50: 666-1313mg\/kg <\/p>\n
Mouse oral LD5O: 375mg\/kg<\/p>\n
Rat dermal LD5O: 1500mg\/ kg<\/p>\n<\/p>\n
\n Slightly harmful to water.\n <\/p>\n
1. Molar refractive index: 48.91<\/p>\n
2. Molar volume (cm3<\/sup>\/mol): 148.4<\/p>\n3. Isotonic specific volume (90.2K ): 397.2<\/p>\n4. Surface tension (dyne\/cm): 51.2<\/p>\n5. Polarizability (10-24cm3): 19.39<\/p>\n<\/p>\nCompute chemical data<\/h2>\n1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n2. Number of hydrogen bond donors: 1<\/p>\n3. Number of hydrogen bond acceptors: 3<\/p>\n4. Number of rotatable chemical bonds: 3<\/p>\n5. Number of tautomers: none<\/p>\n6. Topological molecule polar surface area 46.5<\/p>\n7.Number of heavy atoms: 13<\/p>\n8. Surface charge: 0<\/p>\n9. Complexity: 186<\/p>\n10. Number of isotope atoms: 0<\/p>\n11. Determine the number of atomic stereocenters: 0<\/p>\n12. Uncertain number of atomic stereocenters: 0<\/p>\n13. Determine the number of chemical bond stereocenters: 0<\/p>\n14. Number of uncertain chemical bond stereocenters: 0<\/p>\n15. Number of covalent bond units: 1<\/p>\n<\/p>\nProperties and stability<\/h2>\n\n Avoid contact with oxides and alkalis.\n <\/p>\nStorage method<\/h2>\n\n Store in a cool, ventilated warehouse. Keep away from fire and heat sources. They should be stored separately from oxidants, alkalis, and food chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. Suitable materials should be available in the storage area to contain spills.\n <\/p>\nSynthesis method<\/h2>\n1. First chlorine phenol to prepare 2,4-dichlorophenol. The latter is condensed with chloroacetic acid in the presence of sodium hydroxide to form 2,4-D sodium salt, which is then acidified to form 2,4-D original salt. medicine. Another new process is obtained by condensing phenol and chloroacetic acid under alkaline conditions and then chlorinating it. <\/p>\n2. 2,4-Dichlorophenoxyacetic acid sodium is prepared by heating and refluxing 2,4-dichlorophenol and monochloroacetic acid in NaOH solution, and then acidifying it with hydrochloric acid. <\/p>\n3. Using phenol as raw material, the product can be obtained by first condensation with chloroacetic acid and then chlorination, or by first chlorination and then condensation with chloroacetic acid. (1) Condensation first and then chlorination process. Place the phenol in the reaction kettle, heat and melt it, add 2.2 times (molar ratio) of sodium hydroxide and 1.2 times (molar ratio) of chloroacetic acid, and react at 100-110\u00b0C for 30 minutes. After the reactants are cooled and neutralized with hydrochloric acid, phenoxyacetic acid can be precipitated with a yield of more than 82%. Phenoxyacetic acid is slowly introduced into 1.4-1.6 times (molar ratio) of chlorine gas at 65-90\u00b0C, and the chlorination product is 2,4-difluorophenoxyacetic acid, with a yield of 89%. (2) Chlorination first and then condensation process. Place the molten phenol in a chlorinator and pass chlorine at 45-65\u00b0C for about 8-9 hours. The chlorination reaction ends when the relative density of the reaction material reaches 1.406 (40\u00b0C). Add 30% sodium hydroxide solution to the reactant while it is hot. After heating to boiling, add sodium chloroacetate solution dropwise and reflux for 4-5 hours. After cooling slightly, neutralize to pH 1-3 with 30% hydrochloric acid. Add benzene to extract while hot, and separate the organic layer. After cooling, white crystals precipitate, and the finished product is obtained through suction filtration and drying. <\/p>\n4. Using phenol as raw material, the product can be obtained by first condensation with chloroacetic acid and then chlorination, or by first chlorination and then condensation with chloroacetic acid. Condensation first and then chlorination processPlace phenol in the reactor, heat and melt, add 2.2 times (molar ratio) of sodium hydroxide and 1.2 times (molar ratio) of chloroacetic acid, and React at 100~110\u00b0C for 30 minutes. After the reactants are cooled and neutralized with hydrochloric acid, phenoxyacetic acid can be precipitated with a yield of more than 82%. Phenoxyacetic acid is slowly passed into 1.4 to 1.6 times (molar ratio) of chlorine at 65~90\u00b0C. The chlorination product is 2,4-dichlorophenoxyacetic acid, with a yield of 89%. Chlorination first and then condensation processPlace the molten phenol in a chlorinator and pass chlorine at 45-65\u00b0C for about 8-9 hours. When the relative density of the reaction material reaches 1.406 (40\u00b0C) The chlorination reaction is completed. Add 30% sodium hydroxide solution to the reactant while it is hot. After heating to boiling, add sodium chloroacetate solution dropwise and reflux for 4 to 5 hours. After cooling slightly, neutralize with 30% hydrochloric acid to a Ph value of 1 to 3. Add benzene to extract while hot, and separate the organic layer. After cooling, white crystals precipitate, and the finished product is obtained by suction filtration and drying. <\/p>\n<\/p>\nPurpose<\/h2>\n\n It is used as a herbicide and plant growth agent in agriculture, and is often processed into sodium salt, ammonium salt or ester liquids, powders, emulsions, ointments, etc.\n <\/p>\n extended-reading:https:\/\/www.newtopchem.com\/archives\/44066<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1015<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/5<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/07\/123-1.jpg<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44258<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1891<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1824<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/06\/75.jpg<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40230<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/cas-1067-33-0-3\/<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"Structural formula Business number 0285 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48129,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[24,15116],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48130"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48129"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48130"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
3. Isotonic specific volume (90.2K ): 397.2<\/p>\n
4. Surface tension (dyne\/cm): 51.2<\/p>\n
5. Polarizability (10-24cm3): 19.39<\/p>\n<\/p>\n
1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n
2. Number of hydrogen bond donors: 1<\/p>\n
3. Number of hydrogen bond acceptors: 3<\/p>\n
4. Number of rotatable chemical bonds: 3<\/p>\n
5. Number of tautomers: none<\/p>\n
6. Topological molecule polar surface area 46.5<\/p>\n
7.Number of heavy atoms: 13<\/p>\n
8. Surface charge: 0<\/p>\n
9. Complexity: 186<\/p>\n
10. Number of isotope atoms: 0<\/p>\n
11. Determine the number of atomic stereocenters: 0<\/p>\n
12. Uncertain number of atomic stereocenters: 0<\/p>\n
13. Determine the number of chemical bond stereocenters: 0<\/p>\n
14. Number of uncertain chemical bond stereocenters: 0<\/p>\n
15. Number of covalent bond units: 1<\/p>\n<\/p>\n
\n Avoid contact with oxides and alkalis.\n <\/p>\n
\n Store in a cool, ventilated warehouse. Keep away from fire and heat sources. They should be stored separately from oxidants, alkalis, and food chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. Suitable materials should be available in the storage area to contain spills.\n <\/p>\n
1. First chlorine phenol to prepare 2,4-dichlorophenol. The latter is condensed with chloroacetic acid in the presence of sodium hydroxide to form 2,4-D sodium salt, which is then acidified to form 2,4-D original salt. medicine. Another new process is obtained by condensing phenol and chloroacetic acid under alkaline conditions and then chlorinating it. <\/p>\n
2. 2,4-Dichlorophenoxyacetic acid sodium is prepared by heating and refluxing 2,4-dichlorophenol and monochloroacetic acid in NaOH solution, and then acidifying it with hydrochloric acid. <\/p>\n
3. Using phenol as raw material, the product can be obtained by first condensation with chloroacetic acid and then chlorination, or by first chlorination and then condensation with chloroacetic acid. (1) Condensation first and then chlorination process. Place the phenol in the reaction kettle, heat and melt it, add 2.2 times (molar ratio) of sodium hydroxide and 1.2 times (molar ratio) of chloroacetic acid, and react at 100-110\u00b0C for 30 minutes. After the reactants are cooled and neutralized with hydrochloric acid, phenoxyacetic acid can be precipitated with a yield of more than 82%. Phenoxyacetic acid is slowly introduced into 1.4-1.6 times (molar ratio) of chlorine gas at 65-90\u00b0C, and the chlorination product is 2,4-difluorophenoxyacetic acid, with a yield of 89%. (2) Chlorination first and then condensation process. Place the molten phenol in a chlorinator and pass chlorine at 45-65\u00b0C for about 8-9 hours. The chlorination reaction ends when the relative density of the reaction material reaches 1.406 (40\u00b0C). Add 30% sodium hydroxide solution to the reactant while it is hot. After heating to boiling, add sodium chloroacetate solution dropwise and reflux for 4-5 hours. After cooling slightly, neutralize to pH 1-3 with 30% hydrochloric acid. Add benzene to extract while hot, and separate the organic layer. After cooling, white crystals precipitate, and the finished product is obtained through suction filtration and drying. <\/p>\n
4. Using phenol as raw material, the product can be obtained by first condensation with chloroacetic acid and then chlorination, or by first chlorination and then condensation with chloroacetic acid. Condensation first and then chlorination processPlace phenol in the reactor, heat and melt, add 2.2 times (molar ratio) of sodium hydroxide and 1.2 times (molar ratio) of chloroacetic acid, and React at 100~110\u00b0C for 30 minutes. After the reactants are cooled and neutralized with hydrochloric acid, phenoxyacetic acid can be precipitated with a yield of more than 82%. Phenoxyacetic acid is slowly passed into 1.4 to 1.6 times (molar ratio) of chlorine at 65~90\u00b0C. The chlorination product is 2,4-dichlorophenoxyacetic acid, with a yield of 89%. Chlorination first and then condensation processPlace the molten phenol in a chlorinator and pass chlorine at 45-65\u00b0C for about 8-9 hours. When the relative density of the reaction material reaches 1.406 (40\u00b0C) The chlorination reaction is completed. Add 30% sodium hydroxide solution to the reactant while it is hot. After heating to boiling, add sodium chloroacetate solution dropwise and reflux for 4 to 5 hours. After cooling slightly, neutralize with 30% hydrochloric acid to a Ph value of 1 to 3. Add benzene to extract while hot, and separate the organic layer. After cooling, white crystals precipitate, and the finished product is obtained by suction filtration and drying. <\/p>\n<\/p>\n
\n It is used as a herbicide and plant growth agent in agriculture, and is often processed into sodium salt, ammonium salt or ester liquids, powders, emulsions, ointments, etc.\n <\/p>\n
extended-reading:https:\/\/www.newtopchem.com\/archives\/44066<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1015<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/5<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/07\/123-1.jpg<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44258<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1891<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1824<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/06\/75.jpg<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40230<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/cas-1067-33-0-3\/<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"Structural formula Business number 0285 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48129,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[24,15116],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48130"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48129"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48130"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Structural formula Business number 0285 Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48129,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[24,15116],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48130"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48130\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48129"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48130"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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