{"id":48128,"date":"2024-04-28T15:46:15","date_gmt":"2024-04-28T07:46:15","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/48128"},"modified":"2024-04-28T15:46:15","modified_gmt":"2024-04-28T07:46:15","slug":"l-4-hydroxyproline","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/48128","title":{"rendered":"L-4-Hydroxyproline","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-48127\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/39b5b0d067e14a7487cb7bc5da76b039.gif\" width=\"205\" height=\"227\" alt=\"L-4-hydroxyproline structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>014P<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C5H9NO3<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>131.13<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         L-Hydroxyproline,<\/p>\n<p>                         4-hydroxy-2-carboxypyrrolidine,<\/p>\n<p>                         trans-4-hydroxy-L-proline,<\/p>\n<p>                         (-)-(2S,4R)-4-Hydroxyproline,<\/p>\n<p>                         4-Hydroxy-2-pyrrolidinecarboxylin acid,<\/p>\n<p>                         intermediates,<\/p>\n<p>                         Biochemical reagents<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>51-35-4<\/p>\n<p><b>MDL number:<\/b>MFCD00064320<\/p>\n<p><b>EINECS number:<\/b>200-091-9<\/p>\n<p><b>RTECS number:<\/b>TW3586500<\/p>\n<p><b>BRN number:<\/b>81441<\/p>\n<p><b>PubChem number:<\/b>24880041<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: colorless rhombus or needle-shaped crystals.  Optically active.  <\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): 1.395<\/p>\n<p>3. Relative vapor density (g\/mL, air=1): Undetermined<\/p>\n<p>4. Melting point (\u00baC): 274<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Undetermined<\/p>\n<p>7. Refractive index: Undetermined<\/p>\n<p>8. Flash point (\u00baC): Undetermined<\/p>\n<p>9. Specific rotation (\u00ba): [\u03b1]<sub>D<\/sub>-76.5\u00b0 (C=2.5, in water)<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11. Vapor pressure (  kPa, 25\u00baC): Undetermined<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Undetermined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n<p>14. Critical temperature (\u00baC): Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Oil-water (octanol\/water) partition coefficient relationship  Value: Undetermined<\/p>\n<p>17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit (%, V\/V): Undetermined<\/p>\n<p>19. Solubility: Solubility in water: 288.6g\/L at 0\u2103, 361.1g\/L at 25\u2103, 451.8g\/L at 50\u2103, 516.7g\/L at 65\u2103.  Very slightly soluble in ethanol, insoluble in ether.  <\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     1. Mutagenicity: sister chromatids exchangeTEST system: human lymphocytes: 10mgL\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 29.49<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 93.9<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 263.9<\/p>\n<p>4. Surface tension (dyne\/cm): 62.2<\/p>\n<p>5. Polarizability (10-24cm3): 11.69<\/p>\n<\/p>\n<h2 id=\"js\">Computing chemical data<\/h2>\n<p><p>1. Hydrophobic parameter calculation reference value (XlogP): -3.3<\/p>\n<p>2. Number of hydrogen bond donors: 3<\/p>\n<p>3. Number of hydrogen bond acceptors: 4<\/p>\n<p>  p&gt;<\/p>\n<p>4. Number of rotatable chemical bonds: 1<\/p>\n<p>5. Number of tautomers:<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 69.6<\/p>\n<p>  p&gt;<\/p>\n<p>7. Number of heavy atoms: 9<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 125<\/p>\n<p>10. Number of isotope atoms  : 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 2<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the chemical bond configuration  Number of centers: 0<\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     1. Found in tobacco leaves.\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     1. Protect from light and store in a sealed container.\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>Used as biochemical reagents.  <\/p>\n<\/p>\n<p>     extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31-13.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31-13.jpg<\/a><\/br>extended-reading:<a href=\"https:\/\/www.morpholine.org\/pc41\/\">https:\/\/www.morpholine.org\/pc41\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-T120-1185-81-5-didodecylthio-dibutyltin.pdf\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-T120-1185-81-5-didodecylthio-dibutyltin.pdf<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/45044\">https:\/\/www.newtopchem.com\/archives\/45044<\/a><\/br>extended-reading:<a href=\"https:\/\/www.cyclohexylamine.net\/pc-cat-nmm-addocat-101-tertiary-amine-catalyst-nmm\/\">https:\/\/www.cyclohexylamine.net\/pc-cat-nmm-addocat-101-tertiary-amine-catalyst-nmm\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2021\/05\/2-10.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2021\/05\/2-10.jpg<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44188\">https:\/\/www.newtopchem.com\/archives\/44188<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/cas-2273-43-0-2\/\">https:\/\/www.bdmaee.net\/cas-2273-43-0-2\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/134\">https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/134<\/a><\/br>extended-reading:<a href=\"https:\/\/www.cyclohexylamine.net\/amine-catalyst-smp-delayed-catalyst-smp\/\">https:\/\/www.cyclohexylamine.net\/amine-catalyst-smp-delayed-catalyst-smp\/<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 014P Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48127,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15115],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48128"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48128"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48128\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48127"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48128"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}