{"id":47929,"date":"2024-04-24T14:06:51","date_gmt":"2024-04-24T06:06:51","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47929"},"modified":"2024-04-24T14:06:51","modified_gmt":"2024-04-24T06:06:51","slug":"clomiphene-citrate","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47929","title":{"rendered":"Clomiphene Citrate","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47928\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/04d882131def4da380b34b863f0c2bad.gif\" width=\"353\" height=\"283\" alt=\"Clomiphene Citrate Structural Formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>013M<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C32H36ClNO8<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>598.09<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         1-Chloro-2-[p-(2,-diethylaminoethoxy)phenyl]-1,2-diphenylethyl citrate,<\/p>\n<p>                         Clomiphene citrate,<\/p>\n<p>                         clomiphene,<\/p>\n<p>                         chlorostilbene,<\/p>\n<p>                         Chlorostilamine citrate,<\/p>\n<p>                         Shujingol,<\/p>\n<p>                         Clomiphene dihydrocitrate,<\/p>\n<p>                         N,N-diethyl-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethylamine citrate,<\/p>\n<p>                         2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine,<\/p>\n<p>                         C26H28ClNO\u00b7C6H8O7<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-41-9<\/p>\n<p><b>MDL number:<\/b>MFCD00058322<\/p>\n<p><b>EINECS number:<\/b>200-035-3<\/p>\n<p><b>RTECS number:<\/b>YE0875000<\/p>\n<p><b>BRN number:<\/b>None<\/p>\n<p><b>PubChem number:<\/b>24892851<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>1.<\/SPAN><SPAN>  <\/SPAN><SPAN>Character:<\/SPAN><SPAN>White or milky white crystalline powder<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>2.<\/SPAN><SPAN>  <\/SPAN><SPAN>Density (<\/SPAN><SPAN>g\/mL  ,25\/4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>3.<\/SPAN><SPAN>  <\/SPAN><SPAN>Relative vapor density (<\/SPAN><SPAN>g  \/mL,<\/SPAN><SPAN>AIR<\/SPAN><SPAN>=  1<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>4.<\/SPAN><SPAN>  <\/SPAN><SPAN>Melting point (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>):<\/SPAN><SPAN>116.5-118\u00b0C<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>5.<\/SPAN><SPAN>  <\/SPAN><SPAN>Boiling point (<\/SPAN><SPAN>\u00baC,<\/SPAN><SPAN>Normal pressure): Undetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>6.<\/SPAN><SPAN>  <\/SPAN><SPAN>Boiling point (<\/SPAN><SPAN>\u00baC, 5.2  kPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>7.<\/SPAN><SPAN>  <\/SPAN><SPAN>Refractive index:<\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>8.<\/SPAN><SPAN>  <\/SPAN><SPAN>Flash point (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>9.<\/SPAN><SPAN>  <\/SPAN><SPAN>Specific optical rotation (<\/SPAN><SPAN>\u00ba  <\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>10.<\/SPAN><SPAN>  <\/SPAN><SPAN>Autoignition point or ignition temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>11.<\/SPAN><SPAN>  <\/SPAN><SPAN>Vapor pressure (<\/SPAN><SPAN>kPa,  25 \u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>12.<\/SPAN><SPAN>  <\/SPAN><SPAN>Saturated vapor pressure (<\/SPAN><SPAN>kPa  ,60 \u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>13.<\/SPAN><SPAN>  <\/SPAN><SPAN>Heat of combustion (<\/SPAN><SPAN>KJ\/  mol<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>14.<\/SPAN><SPAN>  <\/SPAN><SPAN>Critical temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>15.<\/SPAN><SPAN>  <\/SPAN><SPAN>Critical pressure (<\/SPAN><SPAN>KPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>16.<\/SPAN><SPAN>  <\/SPAN><SPAN>Oil and water (octanol<\/SPAN><SPAN>\/  <\/SPAN><SPAN>Log value of partition coefficient (water): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>17.<\/SPAN><SPAN>  <\/SPAN><SPAN>Explosion limit (<\/SPAN><SPAN>%,  V\/V<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>18.<\/SPAN><SPAN>  <\/SPAN><SPAN>Lower explosion limit (<\/SPAN><SPAN>%,  V\/V<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>19.<\/SPAN><SPAN>  <\/SPAN><SPAN>Solubility:<\/SPAN><SPAN>Slightly soluble in ethanol, chloroform, water, but not soluble in ether.  <\/SPAN><SPAN><\/SPAN>  <\/P><br \/>\n <P> <\/P>\n     <\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Reference value for hydrophobic parameter calculation (<SPAN>XlogP<\/SPAN>):<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Number of hydrogen bond donors: <SPAN>4<\/SPAN><\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Number of hydrogen bond acceptors: <SPAN>9<\/SPAN><\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Number of rotatable chemical bonds: <SPAN>14<\/SPAN><\/SPAN>  <SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Number of tautomers:<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Topological molecular polar surface area (<SPAN>TPSA<\/SPAN>):<SPAN>145<\/SPAN><\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Number of heavy atoms: <SPAN>42<\/SPAN><\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Surface charge: <SPAN>0<\/SPAN><\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Complexity: <SPAN>708<\/SPAN><\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10  , <\/SPAN><\/SPAN><SPAN>Isotope atomic number: <SPAN>0  <\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11. <\/SPAN><\/SPAN><SPAN>Determine the number of atomic stereocenters: <SPAN>0<\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12. <\/SPAN><\/SPAN><SPAN>The number of uncertain atomic stereocenters: <SPAN>0<\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13. <\/SPAN><\/SPAN><SPAN>Determine the number of stereocenters of chemical bonds: <SPAN>1<\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14. <\/SPAN><\/SPAN><SPAN>Uncertain number of chemical bond stereocenters: <SPAN>0<\/SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>15. <\/SPAN><\/SPAN><SPAN>Number of covalent bond units: <SPAN>2<\/SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN>Sealed in<\/SPAN><SPAN>4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>Save in a dry place and away from light.  <\/SPAN><\/P>\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>4-<\/SPAN><SPAN>Hydroxybenzophenone and diethylaminoethyl chloride hydrochloride  The salt is etherified to obtain p-diethylaminooxybenzophenone. After addition, hydrolysis, elimination, and chlorination, chlorostilbene amine is produced.<\/SPAN><SPAN>[<\/SPAN><SPAN>\uff08<\/SPAN><SPAN>911-45-5]<\/SPAN><SPAN>), and finally use citric acid to form a salt to obtain the product.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P> <\/P>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>This product is an anti-estrogen (fertility inducer), used in gynecological diseases such as functional uterine bleeding, polycystic ovaries, menstrual disorders and drug-induced amenorrhea.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P> <\/P>\n     <\/p>\n<p>     extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-mp601-delayed-equilibrium-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/u-cat-2024-catalyst-cas135083-57-8-sanyo-japan\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/102-3.jpg<\/br>extended-reading:https:\/\/www.bdmaee.net\/butyl-tin-triisooctoate-cas23850-94-4-butyltin-tris\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/cas499-80-9\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/fascat9100-tertiary-amine-catalyst-arkema-butylstannate-pmc\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/694<\/br>extended-reading:https:\/\/www.bdmaee.net\/cas-68298-38-4\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/138<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-RP204-reactive-catalyst&#8211;reactive-catalyst.pdf<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 013M Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47928,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15059],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47929"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47929"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47929\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47928"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47929"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}