{"id":47905,"date":"2024-04-23T15:22:39","date_gmt":"2024-04-23T07:22:39","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47905"},"modified":"2024-04-23T15:22:39","modified_gmt":"2024-04-23T07:22:39","slug":"thalidomide","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47905","title":{"rendered":"thalidomide","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47904\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/8af305fd72f64c45a8c2a97a4d35e819-1.gif\" width=\"203\" height=\"143\" alt=\"Thalidomide structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>013L<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C13H10N2O4<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>258.23<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Mabofloxacin,<\/p>\n<p>                         Marbofloxacin,<\/p>\n<p>                         thalidomide,<\/p>\n<p>                         Phantamidone,<\/p>\n<p>                         N-(2,6-dioxo-3-piperidinyl)-phthalimide,<\/p>\n<p>                         (\u00b1)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione,<\/p>\n<p>                         Zeniquine,<\/p>\n<p>                         sedative<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-35-1<\/p>\n<p><b>MDL number:<\/b>MFCD00153873<\/p>\n<p><b>EINECS number:<\/b>200-031-1<\/p>\n<p><b>RTECS number:<\/b>TI4375000<\/p>\n<p><b>BRN number:<\/b>None<\/p>\n<p><b>PubChem number:<\/b>24278765<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: light yellow crystalline powder, odorless, tasteless<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative  Vapor density (g\/mL, air=1): Undetermined<\/p>\n<p>4. Melting point (\u00baC): 269-271\u00b0C<\/p>\n<p>5. Boiling point (\u00baC, normal pressure):  Undetermined<\/p>\n<p>6. Boiling point (\u00baC, 5.2 kPa): Undetermined<\/p>\n<p>7. Refractive index: Undetermined<\/p>\n<p>8. Flash point (\u00baC):  Undetermined<\/p>\n<p>9. Specific rotation (\u00ba): Undetermined<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11.  Vapor pressure (kPa, 25 \u00baC): Not determined<\/p>\n<p>12. Saturated vapor pressure (kPa, 60 \u00baC): Not determined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Not determined  Determined<\/p>\n<p>14. Critical temperature (\u00baC): Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Oil and water (octanol\/water  ) Log value of distribution coefficient: Undetermined<\/p>\n<p>17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit (%, V\/V): Undetermined  Confirm<\/p>\n<p>19. Solubility: Slightly soluble in water (&lt;0.1 g\/100 mL at 22 \u00baC), ethanol, acetone, insoluble in ether and chloroform.  45% (w\/v) aq 2-hydroxypropyl-\u03b2-cyclodextrin: 0.6 mg\/mL<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 62.35<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 171.7<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 496.5<\/p>\n<p>4. Surface tension (dyne\/cm): 69.9<\/p>\n<p>5. Polarizability (10-24cm3): 24.71<\/p>\n<\/p>\n<h2 id=\"js\">Calculate chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 4<\/p>\n<p>4. Number of rotatable chemical bonds: 1<\/p>\n<p>5. Number of tautomers: 8<\/p>\n<p>6. Topological molecule polar surface area 83.6<\/p>\n<p>7. Number of heavy atoms: 19<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 449<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 1<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed and stored in a dry place away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>It has a certain effect on various types of leprosy reactions, such as fever, nodular erythema, neuralgia, joint pain, lymphadenopathy, etc., but has a slightly less effective effect on tuberculosis-like leprosy reactions.  It has no therapeutic effect on leprosy and can be used together with anti-leprosy drugs to reduce reactions.  The preparation is a tablet.  This product has strong teratogenic effects and is contraindicated in pregnancy.  This medicine should not be used by people without leprosy.  Side effects include dry mouth, dizziness, nausea, abdominal pain, etc.  <\/p>\n<p><\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.cyclohexylamine.net\/polyurethane-thermal-catalyst-thermal-delayed-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/25.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45034<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-amine-catalyst-amine-balance-catalyst\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/677<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/20.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/26<\/br>extended-reading:https:\/\/www.morpholine.org\/dabco-ncm-polyester-sponge-catalyst-dabco-ncm\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/dmea\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/delayed-equilibrium-catalyst-dabco-catalyst\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 013L Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47904,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15055],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47905"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47905"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47905\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47904"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47905"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}