{"id":47899,"date":"2024-04-23T15:17:41","date_gmt":"2024-04-23T07:17:41","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47899"},"modified":"2024-04-23T15:17:41","modified_gmt":"2024-04-23T07:17:41","slug":"ampicillin","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47899","title":{"rendered":"Ampicillin","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47898\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/6859af8a14ce4c87a12f94d8903c19ea-1.gif\" width=\"326\" height=\"227\" alt=\"Ampicillin Structural Formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FP<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C16H19N3O4S<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>349.4<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         ampicillin,<\/p>\n<p>                         aminopenicillin,<\/p>\n<p>                         Phenylbencillin,<\/p>\n<p>                         Benzanaxide,<\/p>\n<p>                         Semicillin,<\/p>\n<p>                         savicillin,<\/p>\n<p>                         ampicillin anhydrous,<\/p>\n<p>                         Ampicillin,<\/p>\n<p>                         (2S,5R,6R)-3,3-dimethyl-6-[(R)-2-amino-2-phenylethylamino]-7-oxo-4-thia-1-azabicyclo[  3.2.0]Heptane-,<\/p>\n<p>                         formic acid,<\/p>\n<p>                         ampicillin,<\/p>\n<p>                         Ampicillin,<\/p>\n<p>                         Genetic engineering research reagents<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>69-53-4<\/p>\n<p><b>MDL number:<\/b>MFCD00005175<\/p>\n<p><b>EINECS number:<\/b>200-709-7<\/p>\n<p><b>RTECS number:<\/b>XH8350000<\/p>\n<p><b>BRN number:<\/b>1090925<\/p>\n<p><b>PubChem number:<\/b>24891442<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: White crystalline powder.  Slightly bitter taste.  <\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative vapor density (g\/mL, air=1): Undetermined<\/p>\n<p>4. Melting point (\u00baC): 200\uff5e202<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa):  Undetermined<\/p>\n<p>7. Refractive index: Undetermined<\/p>\n<p>8. Flash point (\u00baC): Undetermined<\/p>\n<p>9. Specific rotation (\u00ba, C\uff1d  1, in water): +250\u00b15<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Undetermined<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Undetermined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n<p>14. Critical temperature (  \u00baC): Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Log value of oil-water (octanol\/water) partition coefficient: Undetermined<\/p>\n<p>17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit (%, V\/V): Undetermined<\/p>\n<p>19. Solubility:  Soluble in dilute acid and alkali, slightly soluble in water, almost insoluble in chloroform, 96% ethanol, ether and fixed oil.  <\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Moore&#8217;s foldRatio: 89.94<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 239.3<\/p>\n<p>3. Isotonic specific volume (90.2K): 702.7<\/p>\n<p>4. Surface tension (dyne\/cm): 74.3<\/p>\n<p>5. Polarizability (10-24cm3): 35.65<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 3<\/p>\n<p>3. Number of hydrogen bond acceptors: 6<\/p>\n<p>4. Number of rotatable chemical bonds: 4<\/p>\n<p>5. Number of tautomers: 4<\/p>\n<p>6. Topological molecule polar surface area 138<\/p>\n<p>7. Number of heavy atoms: 24<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 562<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 4<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed and stored dry at 4\u00b0C.  Valid for 2 and a half years.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     First, the side chain carboxylic acid of D(-)-phenylglycine is treated with the chlorinating agent PCI5.  It is made into acid chloride and then condensed with 6-APA.  Add acetone and water to the reaction tank, add 6-APA when the temperature reaches -5&#8211;10\u00b0C, and add phenylglycyl chloride hydrochloride. After 0.5 hours of reaction, adjust the pH to 3.5 with 10% sodium hydroxide.  The reactants were extracted with toluene.  Take the aqueous layer and adjust the pH value to about 3.0 with 10% ammonia water.  Decolorize with activated carbon and filter.  The filtrate was then adjusted with ammonia water to make the pH 4.8.  Leave to stand, then filter, wash with acetone, and vacuum dry below 40\u00b0C to obtain the product.  <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     For molecular biology and tissue culture.  Broad-spectrum penicillin can be semi-synthesized.  This product is not resistant to enzymes, stable to acid, and has low toxicity.  It has inhibitory effects on both Gram-negative bacteria and Gram-positive bacteria, and has a strong effect on Escherichia coli, influenzae, Salmonella, Shigella and some Proteus.\n     <\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/butyltin-oxide\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/628<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40372<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/637<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/573<\/br>extended-reading:https:\/\/www.bdmaee.net\/fascat9100-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/niax-lc-5630-thermosensitive-catalyst-momentive\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/fascat8201-tertiary-amine-catalyst-arkema-pmc\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/-B-16-amine-catalyst-B16&#8211;B16.pdf<\/br>extended-reading:https:\/\/www.bdmaee.net\/dabco-ne500-non-emission-amine-catalyst-ne500-strong-gel-amine-catalyst-ne500\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FP Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47898,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15053],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47899"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47899"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47899\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47898"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47899"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}