{"id":47897,"date":"2024-04-23T15:16:05","date_gmt":"2024-04-23T07:16:05","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47897"},"modified":"2024-04-23T15:16:05","modified_gmt":"2024-04-23T07:16:05","slug":"ampicillin-sodium","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47897","title":{"rendered":"ampicillin sodium","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47896\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/75299c247ab046718a7e68610e2348d5-1.gif\" width=\"331\" height=\"227\" alt=\"Ampicillin sodium structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FN<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C16H18N3NaO4S<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>371.38<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         ampicillin sodium,<\/p>\n<p>                         (2S,5R,6R)-3,3-dimethyl-6-[(R)-2-amino-2-phenylacetamido]-7-oxo-4-thia-1-azabicyclo[  3.2.0]Heptane-2-carboxylic acid sodium salt,<\/p>\n<p>                         Sodium [2S-[2\u03b1,5\u03b1,6\u03b2(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate  ,<\/p>\n<p>                         D-(-)-\u03b1-Aminobenzylpenicillin sodium salt<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>69-52-3<\/p>\n<p><b>MDL number:<\/b>MFCD00064313<\/p>\n<p><b>EINECS number:<\/b>200-708-1<\/p>\n<p><b>RTECS number:<\/b>XH8400000<\/p>\n<p><b>BRN number:<\/b>4119211<\/p>\n<p><b>PubChem number:<\/b>24891463<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Characteristics:<\/SPAN>  <SPAN> <\/SPAN><SPAN>White or off-white powder or crystal.  Odorless or slightly odorless, slightly bitter in taste.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Density (<\/SPAN>  <SPAN>g\/mL,25\/4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>):<\/SPAN><SPAN> <\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Relative vapor density (<\/SPAN><SPAN>g\/mL,<\/SPAN><SPAN>Air<\/SPAN><SPAN>=1<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Melting point (<\/SPAN>  <SPAN>\u00baC<\/SPAN><SPAN>): <\/SPAN><SPAN>205<\/SPAN><SPAN>(decomposition)<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Boiling point (<\/SPAN>  <SPAN>\u00baC,<\/SPAN><SPAN>Normal pressure): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Boiling point (<\/SPAN>  <SPAN>\u00baC,5.2kPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Refractive Index: Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Flashpoint (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Specific optical rotation (<\/SPAN><SPAN>\u00ba<\/SPAN><SPAN>,<\/SPAN><SPAN>C<\/SPAN><SPAN>\uff1d<\/SPAN><SPAN>0.2<\/SPAN><SPAN>, in the water<\/SPAN><SPAN>):<\/SPAN><SPAN>+209\u00b0  <\/SPAN><SPAN> <\/SPAN>  <\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Autoignition point or ignition temperature  (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Not  OK<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Vapor pressure (<\/SPAN><SPAN>kPa,25\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Saturation vapor pressure (<\/SPAN><SPAN>kPa,60\u00baC<\/SPAN><SPAN>): Undetermined  <\/SPAN><SPAN><\/SPAN>  <\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>heat of combustion (<\/SPAN><SPAN>KJ\/mol<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Critical temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>15.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Critical Pressure (<\/SPAN><SPAN>KPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>16.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Oil and water (octanol<\/SPAN><SPAN>\/<\/SPAN><SPAN>Water) partition coefficient pair  Number\ufffd\uff1aUndetermined<\/SPAN><SPAN>  <\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>17.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Not  OK<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>18.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Lower explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Not  OK<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>19.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Solubility:<\/SPAN><SPAN>Yes  Hygroscopic.  Easily soluble in water, slightly soluble in acetone and ethanol, slightly soluble in chloroform, insoluble in ether.  <\/SPAN><SPAN><\/SPAN>  <\/P>\n     <\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     <SPAN><SPAN><br \/>\n <SPAN>Acute toxicity: women&#8217;s oral administration<\/SPAN><SPAN>LDLo<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>100 mg\/kg\/5D<\/SPAN><SPAN>  ;Rat Oral Period<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>&gt;5314 mg\/kg<\/SPAN><SPAN>;<\/SPAN><SPAN>Rat abdominal cavity<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>7400 mg\/kg<\/SPAN>  <SPAN>;<\/SPAN><br \/>\n <SPAN> Rat subcutaneous injection<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>&gt;5314 mg\/kg<\/SPAN><SPAN>; <SPAN>Mouse caliber<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>&gt;5314 mg\/kg<\/SPAN><SPAN>;<SPAN>Mouse abdominal cavity<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>5700 mg\/kg<\/SPAN><SPAN>;<\/SPAN><\/SPAN><\/SPAN><br \/>\n <SPAN><SPAN><SPAN> Mouse subcutaneous injection<\/SPAN><SPAN>LD50<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>&gt;5314 mg\/kg; <\/SPAN><SPAN>Rat vein<\/SPAN><SPAN>LDLo  <\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>2657 mg\/kg<\/SPAN><SPAN>; <\/SPAN><\/SPAN><\/SPAN><SPAN><\/SPAN><br \/>\n <P class=\"MsoNormal\" align=\"left\"><\/SPAN><\/SPAN> <\/P>\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Hydrogen Bonding  Number of donors: <\/SPAN><SPAN>2<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Hydrogen Bonding  Number of receptors: <\/SPAN><SPAN>5<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Rotatable  Number of chemical bonds: <\/SPAN><SPAN>4<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Interchange  Number of isomers: <\/SPAN><SPAN>2<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Topological molecules  Polar surface area (<\/SPAN><SPAN>TPSA<\/SPAN><SPAN>\uff09\uff1a<\/SPAN><SPAN>116<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Heavy atoms  Quantity: <\/SPAN><SPAN>25<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Surface charge  \uff1a<\/SPAN><SPAN>0<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8. <SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Complexity  \uff1a<\/SPAN><SPAN>568<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Isotope atomic number:<\/SPAN><SPAN>0<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Determine the number of atomic stereocenters:<\/SPAN><SPAN>4<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Uncertain number of atomic stereocenters:<\/SPAN><SPAN>0<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Determine the number of stereocenters of chemical bonds:<\/SPAN><SPAN>0<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Uncertain number of chemical bond stereocenters:<\/SPAN><SPAN>0<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Number of covalent bond units:<\/SPAN>  <SPAN>2<\/SPAN><\/P>\n     <\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN> <\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>This product should be sealed in<\/SPAN><SPAN>4<\/SPAN><SPAN>\u2103<\/SPAN><SPAN>Preserve dry.  Validity period<\/SPAN><SPAN>2<\/SPAN><SPAN>year and a half.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><\/SPAN><SPAN> <SPAN><\/SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN>Obtained from the salt formation of ampicillin: suspend ampicillin in water and adjust with sodium hydroxide solution<\/SPAN><SPAN>pH<\/SPAN><SPAN>to<\/SPAN><SPAN>9<\/SPAN><SPAN>, dissolve, filter.  Add activated carbon to the filtrate to decolorize, filter, and dry the filtrate at low temperature to obtain the product.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     <SPAN><\/SPAN><SPAN><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN>For molecular biology and tissue culture (to prevent microbial contamination).  <\/SPAN><SPAN> <\/P><br \/>\n <P class=\"MsoNormal\"><SPAN>Ampicillin sodium-basedThe bactericidal ingredients in \ufffd\ufffd act on the active reproduction stage of bacteria and exert a bactericidal effect by inhibiting the biosynthesis of cell wall mucopeptides.  <\/SPAN><\/P><SPAN><\/SPAN><\/SPAN><\/SPAN>\n     <\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/butyltin-oxide\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/07\/86.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/940<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/high-quality-tmr-2-cas-62314-25-4-2-hydroxypropyltrimethylammoniumformate\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/amine-catalyst-smp\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/lupragen-n203-teda-l33e\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40057<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44254<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-delayed-polyurethane-catalyst-dabco-delayed-catalyst\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/semi-rigid-foam-catalyst-tmr-4-dabco-tmr\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FN Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47896,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15052],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47897"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47897"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47897\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47896"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47897"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}