{"id":47874,"date":"2024-04-23T14:56:13","date_gmt":"2024-04-23T06:56:13","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47874"},"modified":"2024-04-23T14:56:13","modified_gmt":"2024-04-23T06:56:13","slug":"d-cycloserine","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47874","title":{"rendered":"D-cycloserine","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47873\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/12f7bc9f3e1940bab3fdcc75d53aa0a6-1.gif\" width=\"255\" height=\"227\" alt=\"D-cycloserine structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FD<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C3H6N2O2<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>102.09<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         (R)-(+)-cycloserine,<\/p>\n<p>                         D-4-amino-3-isoxazolidinone,<\/p>\n<p>                         cycloserine,<\/p>\n<p>                         D-4-amino-3-isoxazolidinone,<\/p>\n<p>                         4-Amino-3-isoxazolidinone,<\/p>\n<p>                         (R)-4-Amino-3-isoxazolidinone,<\/p>\n<p>                         Cycloserine,<\/p>\n<p>                         Genetic engineering research reagents<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>68-41-7<\/p>\n<p><b>MDL number:<\/b>MFCD00005353<\/p>\n<p><b>EINECS number:<\/b>200-688-4<\/p>\n<p><b>RTECS number:<\/b>NY2975000<\/p>\n<p><b>BRN number:<\/b>80798<\/p>\n<p><b>PubChem number:<\/b>24892907<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: Colorless needle-like or leaf-like crystals or amorphous powder<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Uncertain<\/p>\n<p>3  . Relative vapor density (g\/mL, air=1): Uncertain<\/p>\n<p>4. Melting point (\u00baC): 155-156 (decomposition)<\/p>\n<p>5. Boiling point (\u00baC, normal  Pressure): Uncertain<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Uncertain<\/p>\n<p>7. Refractive index: Uncertain<\/p>\n<p>8. Flash point (  \u00baC): Uncertain<\/p>\n<p>9. Specific optical rotation (\u00ba): 111 \u00ba (C=5, 2N NaOH)<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC):  Uncertain<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Uncertain<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Uncertain<\/p>\n<p>13.  Heat of combustion (KJ\/mol): Uncertain<\/p>\n<p>14. Critical temperature (\u00baC): Uncertain<\/p>\n<p>15. Critical pressure (KPa): Uncertain<\/p>\n<p>16. The logarithmic value of the oil-water (octanol\/water) partition coefficient: Uncertain<\/p>\n<p>17. The upper explosion limit (%, V\/V): Uncertain<\/p>\n<p>18. The lower explosion limit  (%, V\/V): Uncertain<\/p>\n<p>19. Solubility: Soluble in water, slightly soluble in methanol, ethanol, butanol, propylene glycol, isopropyl alcohol and acetone, hardly soluble or insoluble in toluene,  Chloroform, ether, pyridine, benzene and carbon disulfide<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 22.47<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 79.8<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 201.9<\/p>\n<p>4. Surface tension (dyne\/cm): 40.8<\/p>\n<p>5. Polarizability (10-24cm3): 8.90<\/p>\n<\/p>\n<h2 id=\"js\">Computing chemical data<\/h2>\n<p><p>1. Hydrophobic parameter calculation reference value (XlogP): -1.5<\/p>\n<p>2. Number of hydrogen bond donors: 2<\/p>\n<p>3. Number of hydrogen bond acceptors: 3<\/p>\n<p>  p&gt;<\/p>\n<p>4. Number of rotatable chemical bonds: 0<\/p>\n<p>5. Number of tautomers: 5<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 64.4<\/p>\n<p>7. Number of heavy atoms: 7<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 92.9<\/p>\n<p>10. Isotopic atoms  Quantity: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 1<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the chemical bond establishment  Number of stereocenters: 0<\/p>\n<p>14, Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15, Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed and stored in a cool, dry place away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>Cycloserine can be prepared by fermentation or direct synthesis.  The bacteria produced by the fermentation method is Actinomyces laven-dulae, and the fermentation medium is dextrin, glucose, starch, soybean cake powder, yeast powder, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate  and soybean oil, etc.  The synthesis method is to react \u03b2-aminooxyalanine ethyl ester dihydrochloride with potassium hydroxide to obtain cycloserine through cyclization.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>Antibiotic drugs.  For infections caused by drug-resistant Mycobacterium tuberculosis.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/cell-improvement-agent\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/bis3-dimethylaminopropylamino-2-propanol\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-t-12-tin-catalyst-dabco-t-12-catalyst-t-12\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/nt-cat-la-300-catalyst-cas10861-07-1-newtopchem\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/niax-b-4-tertiary-amine-catalyst-momentive\/<\/br>extended-reading:https:\/\/www.morpholine.org\/category\/morpholine\/page\/5390\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/45087<\/br>extended-reading:https:\/\/www.bdmaee.net\/dibutyl-tin-bis-1-thioglycerol\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1677<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-delay-type-catalyst-delay-type-strong-gel-catalyst\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FD Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47873,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15041],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47874"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47874"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47874\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47873"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47874"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}