{"id":47868,"date":"2024-04-23T14:04:47","date_gmt":"2024-04-23T06:04:47","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47868"},"modified":"2024-04-23T14:04:47","modified_gmt":"2024-04-23T06:04:47","slug":"sulfadiazine","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47868","title":{"rendered":"sulfadiazine","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47867\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/a00cab060dba49e18496452dd01cad14-5.gif\" width=\"198\" height=\"237\" alt=\"Sulfadiazine Structural Formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>01FB<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C10H10N4O2S<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>250.28<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         sulfadiazine,<\/p>\n<p>                         2-p-Aminobenzenesulfonamidepyrimidine,<\/p>\n<p>                         Diyajing,<\/p>\n<p>                         sulfapyridazine,<\/p>\n<p>                         zinc sulfadiazine,<\/p>\n<p>                         N-2-pyrimidinyl-4-aminobenzenesulfonamide,<\/p>\n<p>                         great tranquility,<\/p>\n<p>                         xiafadiajing<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>68-35-9<\/p>\n<p><b>MDL number:<\/b>MFCD00006065<\/p>\n<p><b>EINECS number:<\/b>200-685-8<\/p>\n<p><b>RTECS number:<\/b>WP1925000<\/p>\n<p><b>BRN number:<\/b>6733588<\/p>\n<p><b>PubChem number:<\/b>24899802<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Character: white or off-white crystal or powder, odorless, tasteless, gradually darkens when exposed to light<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Uncertain<\/p>\n<p>3. Relative vapor density (g\/mL, air=1): Uncertain<\/p>\n<p>4. Melting point (\u00baC): 253 (dec.)(lit.)<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Uncertain<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Uncertain<\/p>\n<p>7. Refractive index: Uncertain<\/p>\n<p>8. Flash point (\u00baC): Uncertain<\/p>\n<p>9. Specific rotation (\u00ba): Uncertain<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC):  Uncertain<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Uncertain<\/p>\n<p>12. Saturated vapor pressure (kPa, 60\u00baC): Uncertain<\/p>\n<p>13.  Heat of combustion (KJ\/mol): Uncertain<\/p>\n<p>14. Critical temperature (\u00baC): Uncertain<\/p>\n<p>15. Critical pressure (KPa): Uncertain<\/p>\n<p>16. The logarithmic value of the oil-water (octanol\/water) partition coefficient: Uncertain<\/p>\n<p>17. The upper explosion limit (%, V\/V): Uncertain<\/p>\n<p>18. The lower explosion limit  (%, V\/V): Uncertain<\/p>\n<p>19. Solubility: Almost insoluble in water. At 37\u00b0C, the solubility in water with pH=5.6 is 13mg\/100ml, and the solubility in water with pH=7.5 is 13mg\/100ml.  200mg\/100ml.  Slightly soluble in ethanol or acetone, easily soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 63.14<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 167.2<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 504.4<\/p>\n<p>4. Surface tension (dyne\/cm): 82.6<\/p>\n<p>5. Polarizability (10-24cm3): 25.03<\/p>\n<\/p>\n<h2 id=\"js\">Computing chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 2<\/p>\n<p>3. Number of hydrogen bond acceptors: 6<\/p>\n<p>4. Number of rotatable chemical bonds: 3<\/p>\n<p>5. Number of tautomers: 2<\/p>\n<p>6. Topological molecule polar surface area 106<\/p>\n<p>7. Number of heavy atoms: 17<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 327<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>Store in an airtight container away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>It can be prepared by synthesizing 2-aminopyrimidine from furochloric acid and nitroguanidine, and then condensing and hydrolyzing it with p-acetylbenzenesulfonyl chloride in pyridine.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>This product is a medium-effective sulfonamide for the treatment of systemic infections. It has a broad antibacterial spectrum and has inhibitory effects on most Gram-positive and negative bacteria. It is effective against Neisseria meningitidis, Streptococcus pneumoniae, Neisseria gonorrhoeae, and hemolytic chain bacteria.  The inhibitory effect of cocci is strong and can penetrate into the cerebrospinal fluid through the blood-brain barrier.  <\/p>\n<p>It is mainly used clinically for meningococcal meningitis and is the first choice drug for treating meningococcal meningitis. It can also treat other infections caused by the above-mentioned sensitive bacteria.  It is also often made into a water-soluble sodium salt and used as an injection.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.newtopchem.com\/archives\/873<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/31-6.jpg<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/rigid-foam-catalyst-semi-rigid-foam-catalyst\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/143<\/br>extended-reading:https:\/\/www.bdmaee.net\/low-odor-reactive-composite-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/nnn-trimethyl-n-hydroxyethyl-bisaminoethyl-ether-cas-83016-70-0-jeffcat-zf-10\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1025<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/38<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Catalyst-A400-A400-polyurethane-catalyst-A400.pdf<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/high-quality-dmcha-cas-98-94-2-n-dimethylcyclohexylamine\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 01FB Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47867,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15034],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47868"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47868"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47868\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47867"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47868"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}