{"id":47856,"date":"2024-04-23T14:04:00","date_gmt":"2024-04-23T06:04:00","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47856"},"modified":"2024-04-23T14:04:00","modified_gmt":"2024-04-23T06:04:00","slug":"hydrocortisone","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47856","title":{"rendered":"hydrocortisone","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47855\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/c6498eb892bc45008702280917677294-5.gif\" width=\"215\" height=\"127\" alt=\"Hydrocortisone structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>013B<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C21H30O5<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>362.46<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Yes,<\/p>\n<p>                         Cordazole,<\/p>\n<p>                         cortisol,<\/p>\n<p>                         hydrocortisone,<\/p>\n<p>                         17-Hydroxycorticosterone,<\/p>\n<p>                         cortisol,<\/p>\n<p>                         Hydrocortin,<\/p>\n<p>                         Hydrocorticosterone,<\/p>\n<p>                         11\u03b2,17\u03b1,21-trihydroxypregnant-4-en-3,20-dione,<\/p>\n<p>                         Hydrogenated adrenocorticoid hormone,<\/p>\n<p>                         Hydroprednisolone,<\/p>\n<p>                         11\u03b2,17\u03b1,21-Trihydroxypregn-4-ene-3,20-dione,<\/p>\n<p>                         17-Hydroxycorticosterone,<\/p>\n<p>                         4-Pregnene-11\u03b2,17\u03b1,21-triol-3,20-dione,<\/p>\n<p>                         Cortisol,<\/p>\n<p>                         Kendall&#8217;s compound F,<\/p>\n<p>                         Reichstein&#8217;s substance M<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-23-7<\/p>\n<p><b>MDL number:<\/b>MFCD00011654<\/p>\n<p><b>EINECS number:<\/b>200-020-1<\/p>\n<p><b>RTECS number:<\/b>GM8925000<\/p>\n<p><b>BRN number:<\/b>1354819<\/p>\n<p><b>PubChem number:<\/b>24278466<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: White or off-white crystalline powder, odorless and bitter in taste.  Deterioration when exposed to light<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative vapor density (g\/mL, air=1): Undetermined  <\/p>\n<p>4. Melting point (\u00baC): 214-220\u2103 (decomposition); <\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6.  Boiling point (\u00baC, 5.2 kPa): Not determined<\/p>\n<p>7. Refractive index: Not determined<\/p>\n<p>8. Flash point (\u00baC): 220<\/p>\n<p>9. Ratio  Optical rotation (\u00ba): [\u03b1]<sup>25<\/sup><sub>D<\/sub>+157.5\u00b0 (dioxane), +176\u00b0 (chloroform), +162\u00b0-+169\u00b0 (ethanol  );<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11. Vapor pressure (kPa, 25 \u00baC): Undetermined<\/p>\n<p>  12. Saturated vapor pressure (kPa, 60 \u00baC): Undetermined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n<p>14. Critical temperature (\u00baC): Undetermined  <\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Log value of oil-water (octanol\/water) partition coefficient: Undetermined<\/p>\n<p>17.  Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit\ufffd (%, V\/V): Undetermined<\/p>\n<p>19. Solubility: Insoluble in water (H<sub>2<\/sub>O: 100 mg\/mL), hardly soluble in ether, slightly  Soluble in chloroform, soluble in acetone and ethanol.  Soluble in concentrated sulfuric acid and showing green fluorescence<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 95.57<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 281.3<\/p>\n<p>3. Isotonic specific volume (90.2K  ): 779.2<\/p>\n<p>4. Surface tension (dyne\/cm): 58.8<\/p>\n<p>5. Polarizability (10-24cm3): 37.88<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 3<\/p>\n<p>3. Number of hydrogen bond acceptors: 5<\/p>\n<p>4. Number of rotatable chemical bonds: 2<\/p>\n<p>5. Number of tautomers: 15<\/p>\n<p>6. Topological molecule polar surface area 94.8<\/p>\n<p>7. Number of heavy atoms: 26<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 684<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 7<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed and stored in a dry place away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     It can be separated from the adrenal gland fluid, or it can be made from 17\u03b1-hydroxyflavone as raw material through a series of reactions.\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     Mainly used to rescue critical toxic infections; treat meningitis, pleurisy, arthritis, tenosynovitis, sprains, muscle strains, etc.  It can also be used for rheumatoid arthritis, rheumatic fever, bronchial asthma, gout, atopic dermatitis, and itching.  In addition, it can also be used for keratitis, scleritis, conjunctivitis, iridocyclitis, etc.  <\/p>\n<p>     extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Dibutyltin-diacetate-CAS1067-33-0-dibutyl-tin-diacetate.pdf<\/br>extended-reading:https:\/\/www.morpholine.org\/cas-67151-63-7\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/911<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1817<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44053<\/br>extended-reading:https:\/\/www.bdmaee.net\/cas-870-08-6\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/756<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/polyurethane-catalyst-dabco-dc2-strong-gel-catalyst-dabco-dc2\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/polycat-37-low-odor-polyurethane-rigid-foam-catalyst-low-odor-polyurethane-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/nt-cat-pc12-catalyst-cas10144-28-9-newtopchem\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 013B Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[10413],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47856"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47856"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47856\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47855"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47856"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47856"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47856"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}