{"id":47843,"date":"2024-04-23T14:03:09","date_gmt":"2024-04-23T06:03:09","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47843"},"modified":"2024-04-23T14:03:09","modified_gmt":"2024-04-23T06:03:09","slug":"ergocalciferol","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47843","title":{"rendered":"Ergocalciferol","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47842\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/cd7e464550444c6eb86e233b0215aafc-5.gif\" width=\"251\" height=\"218\" alt=\"Ergocalciferol structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>0138<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C28H44O<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>396.66<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         Vitamin D2,<\/p>\n<p>                         Butyrosin,<\/p>\n<p>                         calciferol,<\/p>\n<p>                         Calciferol,<\/p>\n<p>                         Ercalciol,<\/p>\n<p>                         Ergosterol irradiated,<\/p>\n<p>                         Irradiated ergosterol,<\/p>\n<p>                         Vitamin D2,<\/p>\n<p>                         Nutrition supplements<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-14-6<\/p>\n<p><b>MDL number:<\/b>MFCD00166988<\/p>\n<p><b>EINECS number:<\/b>200-014-9<\/p>\n<p><b>RTECS number:<\/b>KE1050000<\/p>\n<p><b>BRN number:<\/b>1916682<\/p>\n<p><b>PubChem number:<\/b>24894344<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: White needle-like crystals or crystalline powder, odorless and tasteless.  Reduced activity when exposed to oxygen or light<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative vapor density (g\/mL, air=1)  : Undetermined<\/p>\n<p>4. Melting point (\u00baC): 115-118 (decomposition)<\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6  . Boiling point (\u00baC, 5.2 kPa): Not determined<\/p>\n<p>7. Refractive index: Not determined<\/p>\n<p>8. Flash point (\u00baC): Not determined<\/p>\n<p>9  . Specific rotation (\u00ba): 82 \u00ba (c=3, in acetone 25 \u00baC)<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11.  Vapor pressure (kPa, 25 \u00baC): Not determined<\/p>\n<p>12. Saturated vapor pressure (kPa, 60 \u00baC): Not determined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Not determined  Determined<\/p>\n<p>14. Critical temperature (\u00baC): Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Oil and water (octanol\/water  ) Log value of distribution coefficient: Undetermined<\/p>\n<p>17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n<p>18. Explosion lower limit (%, V\/V): Undetermined  Confirm<\/p>\n<p>19. Solubility: Easily soluble in ethanol (1:2), ether (1:2), acetone (1:10) and chloroform (1:0.7), insoluble in water (H<sub>2<\/sub>O: 200 mg\/mL, clear to hazy);<span style=\"font-family:Arial\">Easily soluble in chloroform.  Easily soluble in ethanol, acetone or ether, slightly soluble in vegetable oil.  <\/span><\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     <span style=\"font-family:Arial\">Guinea pig oral<span style=\"font-family:Arial\">LD50:4<\/span>0<span style=\"font-family:Arial\">  mg\/kg<\/span>.  <\/span>\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>None\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): 7.4<\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 1<\/p>\n<p>4. Number of rotatable chemical bonds: 5<\/p>\n<p>5. Number of tautomers:<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 20.2<\/p>\n<p>7. Number of heavy atoms: 29<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 678<\/p>\n<p>10. Number of isotope atoms:  0<\/p>\n<p>11. Determine the number of atomic stereocenters: 6<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters  Number: 3<\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p><p>This product should be sealed with argon gas and stored in a dry place at 4\u00b0C away from light.  <\/p>\n<\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>1. Dissolve ergosterol in ethanol, open the ring under UV irradiation, concentrate the reaction solution under reduced pressure, freeze and filter.  Filtrate the liquid nitrogen and concentrate to dryness under reduced pressure to obtain vitamin D2 crude oil, which is refined to obtain the finished product.  <\/p>\n<p><span style=\"font-family:Arial\">2. Vitamin D2 naturally exists in liver, milk and egg yolk. Industrially, ergocalciferol, which cannot be absorbed by the human body, is often extracted from vegetable oil or yeast.  , dissolved in chloroform or cyclohexane, converted into vitamin D2 by ultraviolet irradiation.  <\/span><\/p>\n<p><span style=\"font-family:Arial\">3.<span style=\"font-family:Arial\">Ergosterol isolated from beer yeast, shiitake mushrooms, etc.,  Dissolve in solvents such as chloroform, ether or cyclohexane, add it to a flask made of quartz glass, and obtain it by irradiating it with ultraviolet light.  <\/span><br \/><\/span><\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     1. Mainly used for the prevention and treatment of rickets; osteomalacia; infantile tetany, etc.  2.<span style=\"font-family:Arial\">Vitamin D2 can maintain the normal metabolism of calcium and phosphorus, promote the absorption of calcium and phosphorus in the small intestine, maintain the normal ratio of calcium and phosphorus in the blood, and turn calcium into phosphoric acid  Calcium is deposited into bones, flesh and tissues.  Insufficient intake can lead to rickets, osteomalacia, etc.  Our country stipulates that it can be used to fortify margarine, the usage amount is 125-156\u03bcg\/kg; the usage amount in fortified dairy products is 63-125\u03bcg\/kg; the usage amount in fortified infant food is 50-100\u03bcg\/kg; in fortified milk and  The usage amount in milk drinks is 10-40\u03bcg\/kg; the maximum usage amount in fortified solid drinks and ice cream is 10-20\u03bcg\/kg.  It is usually used together with vitamin A in food.  <\/span>3.<span style=\"font-family:Arial\">Used in cosmetics, it can prevent dry skin, eczema, and abnormal nails and hair.  <\/span>\n     <\/p>\n<p>     extended-reading:https:\/\/www.morpholine.org\/dimethomorph\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/fentacat-100le-catalyst-cas13355-70-2-solvay\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/strong-gel-amine-catalyst-ne500-dabco-strong-gel-amine-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/catalyst-9726\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/fentacat-f50-catalyst-cas122695-73-9-solvay\/<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44126<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2020\/07\/NEWTOP4.jpg<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/586<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44412<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/40065<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 0138 Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47842,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15029],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47843"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47843"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47843\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47842"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47843"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}