{"id":47837,"date":"2024-04-23T14:02:48","date_gmt":"2024-04-23T06:02:48","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/47837"},"modified":"2024-04-23T14:02:48","modified_gmt":"2024-04-23T06:02:48","slug":"cortisone-acetate","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/47837","title":{"rendered":"cortisone acetate","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-47836\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/04\/6235dc6b26904c8688925ddcdcf18d11-6.gif\" width=\"256\" height=\"175\" alt=\"Cortisone acetate structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>0135<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C23H30O6<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>402.48<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         cortisone acetate,<\/p>\n<p>                         cortisone acetate,<\/p>\n<p>                         progesterone acetate,<\/p>\n<p>                         cortisol,<\/p>\n<p>                         corticosterone acetate,<\/p>\n<p>                         Pregnant-4-ene-17\u03b1,<\/p>\n<p>                         21-Diol-3,11,20-trione-21-acetate,<\/p>\n<p>                         21-acetoxy-17\u03b1,<\/p>\n<p>                         Hydroxypregnant-4-ene-3,11,20-trione,<\/p>\n<p>                         cortisone 21-acetate,<\/p>\n<p>                         11-dehydro-17-hydroxycorticosterone acetate,<\/p>\n<p>                         11-dehydro-17-hydroxycorticosterone-21-acetate,<\/p>\n<p>                         17,21-dihydroxypregn-4-ene-3,11,20-trione acetat,<\/p>\n<p>                         hormone<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>50-04-4<\/p>\n<p><b>MDL number:<\/b>MFCD00003609<\/p>\n<p><b>EINECS number:<\/b>200-006-5<\/p>\n<p><b>RTECS number:<\/b>GM9140000<\/p>\n<p><b>BRN number:<\/b>2067543<\/p>\n<p><b>PubChem number:<\/b>24278306<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p><p>1. Properties: White or off-white crystalline powder, odorless<\/p>\n<p>2. Density (g\/mL, 25\/4\u2103): Undetermined<\/p>\n<p>3. Relative  Vapor density (g\/mL, air=1): Not determined<\/p>\n<p>4. Melting point (\u00baC): 237-240 \u00b0C.  <\/p>\n<p>5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n<p>6. Boiling point (\u00baC, 5.2kPa): Undetermined<\/p>\n<p>7. Refractive index:  212 \u00b0 (C=1, MeOH)<\/p>\n<p>8. Flash point (\u00baC): 223<\/p>\n<p>9. Specific rotation (\u00ba): [\u03b1]25D+166\u00b0<\/p>\n<p>10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n<p>11. Vapor pressure (kPa, 25\u00baC): Undetermined<\/p>\n<p>12. Saturated vapor pressure  (kPa, 60\u00baC): Undetermined<\/p>\n<p>13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n<p>14. Critical temperature (\u00baC): Undetermined<\/p>\n<p>15. Critical pressure (KPa): Undetermined<\/p>\n<p>16. Log value of oil-water (octanol\/water) distribution coefficient: Undetermined<\/p>\n<p>17. Explosion upper limit (%, V  \/V): Undetermined<\/p>\n<p>18. Lower explosion limit (%, V\/V): Undetermined<\/p>\n<p>19. Solubility: Undetermined<\/p>\n<\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p><p>1. Acute toxicity: mouse abdominal LD50: 35 mg\/kg; <\/p>\n<p>2. Teratogenicity: Bacillus subtilis test: 5 gm\/L<\/p>\n<p>3. Reproduction  Toxicity<\/p>\n<p>Rat caliber TDLo: maternal 300 mg\/kg; rat caliber TDLo: paternal 56mg\/kg;<\/p>\n<p>Rat abdominal TDLo: 800 mg\/kg; rat subcutaneous  TDLo: 400 mg\/kg, 1-8 days of pregnancy\ufffd\ufffdRat subcutaneous TDLo: 500 mg\/kg, 12-13 days of pregnancy;<\/p>\n<p>Rat muscle TDLo: 300mg\/kg, 12-15 days of pregnancy; Rat muscle TDLo: 500mg\/kg, 8 days of pregnancy  -17 days; rat muscle TDLo: 700mg\/kg, pregnancy day 16-22;<\/p>\n<p>Rat intestinal TDLo: 600 mg\/kg, pregnancy day 7-14; rat intestinal TDLo: 60  mg\/kg, 16-19 days of pregnancy<\/p>\n<p>Mouse abdominal TDLo: 182 mg\/kg, 13 days of pregnancy; Mouse abdominal TDLo: 400mg\/kg, 8-11 days of pregnancy;<\/p>\n<p>Mouse subcutaneous TDLo: 100 mg\/kg, pregnancy day 9-12; mouse subcutaneous TDLo: 122 mg\/kg, pregnancy day 13; mouse subcutaneous TDLo: 50 mg\/kg, pregnancy 14 days;<\/p>\n<p>Mouse muscle TDLo: 200mg\/kg, pregnancy day 11-12; mouse muscle TDLo: 96mg\/kg, pregnancy day 13; mouse muscle TDLo: 200mg\/kg, pregnancy 11-14 days<\/p>\n<p>Mouse intestinal TDLo: 100 mg\/kg;<\/p>\n<p>Dog muscle TDLo: 150 mg\/kg;<\/p>\n<p>Rabbit muscle TDLo: 25 mg\/kg; Rabbit eye TDLo: 2880  ug\/kg;<\/p>\n<\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p><p>Generally not hazardous to water, do not discharge material into the surrounding environment without government permission.  <\/p>\n<\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p><p>1. Molar refractive index: 103.75<\/p>\n<p>2. Molar volume (cm<sup>3<\/sup>\/mol): 318.1<\/p>\n<p>  3. Isotonic specific volume (90.2K): 858.0<\/p>\n<p>4. Surface tension (dyne\/cm): 52.8<\/p>\n<p>5. Polarizability (10-24cm3): 41.13<\/p>\n<\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): 2.1<\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 6<\/p>\n<p>4. Number of rotatable chemical bonds: 4<\/p>\n<p>5. Number of tautomers: 30<\/p>\n<p>6. Topological molecular polar surface area (TPSA): 97.7<\/p>\n<p>7. Number of heavy atoms: 29<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 827<\/p>\n<p>10. Number of isotope atoms  : 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 6<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the chemical bond configuration  Number of centers: 0<\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p><p>White needle-like crystals or crystalline powder (acetone), odorless.  Stable in air.  Mp239- 241\u2103, specific optical rotation [\u03b1]<sup>20<\/sup><sub>D<\/sub>+164\u00b0 (0.5%, acetone), [\u03b1]<sup>23<\/sup><sub>D<\/sub>+169\u00b0(chloroform), [\u03b1]<sup>25<\/sup><sub>D<\/sub>+208\u00b0-+217\u00b0(dioxane), ethanol of this product  The solution has maximum absorption at a wavelength of 240nm.  Easily soluble in chloroform (1:4), soluble in acetone (1:75), slightly soluble in ethanol and ether, and insoluble in water.  This product dissolves in sulfuric acid and is yellow without fluorescence (different from hydrocortisone acetate).  <\/p>\n<\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     Shield from light and store in a sealed container.\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p><p>1. It is prepared by epoxidation, Wohlmann&#8217;s oxidation, mold oxidation, chromic acid oxidation, hydrogen bromide ring opening, Raney nickel catalytic debromination, iodination and acetoxy replacement of gestational dienolone;  <\/p>\n<p>2. Using progesterone acetate as raw material, 11-keto-16, 17\u03b1 epoxy can be obtained through hydrogen oxide oxidation, Wohlmann&#8217;s oxidation, black rhizome biological oxidation, and chromic anhydride oxidation.  Progesterone is obtained by ring-opening with hydrobromic acid, hydrodebromination to obtain cortisone, which reacts with iodine, reacts with molten potassium acetate to obtain a crude product, and finally recrystallizes.  <\/p>\n<\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p><p>Biochemical research, adrenocortical hormone drugs, with anti-inflammatory and anti-allergic effects; intermediate of prednisone acetate.  It is an anti-inflammatory agent in itself.  It is used to treat adrenocortical hypofunction, rheumatoid arthritis, rheumatism, lupus erythematosus and other diseases.  <\/p>\n<\/p>\n<p>     extended-reading:https:\/\/www.newtopchem.com\/archives\/44729<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/134-1.jpg<\/br>extended-reading:https:\/\/www.bdmaee.net\/dibutyl-tin-diacetate\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/pc-cat-nmm-catalyst\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/Dibutyltin-dilaurate-CAS77-58-7-dibutyl-tin-dilaurate.pdf<\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/113<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/methyl-tin-maleate-powder-methyltin-maleate\/<\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/dabco-bl-11-niax-a-1-jeffcat-zf-22\/<\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/129-4.jpg<\/br>extended-reading:https:\/\/www.bdmaee.net\/fentacat-26-catalyst-cas111542-55-9-solvay\/<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 0135 Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":47836,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[9410],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47837"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=47837"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/47837\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/47836"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=47837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=47837"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=47837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}